{"id":"W2566136618","doi":"10.1212/wnl.86.16_supplement.p3.061","title":"Rate of Brain Volume Loss with Long-Term Delayed-Release Dimethyl Fumarate Treatment in Patients with Relapsing-Remitting Multiple Sclerosis: 6-Year Results from ENDORSE (P3.061)","year":2016,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Dimethyl fumarate; Relapsing remitting; Multiple sclerosis; Medicine; Chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003255334,0.000399599,0.001122751,0.0003099792,0.0002480252,0.0004862542,0.0003492474,0.0005694258,0.0005833296],"category_scores_gemma":[0.002916107,0.0002274303,0.00103562,0.0003545678,0.0002361639,0.0006078532,0.0003955925,0.0008104815,0.0001408475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003226942,"about_ca_system_score_gemma":0.0002434621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006851704,"about_ca_topic_score_gemma":0.000981442,"domain_scores_codex":[0.9989067,0.0005572309,0.00009450667,0.000153868,0.0002077267,0.00007989035],"domain_scores_gemma":[0.9970163,0.0006495071,0.001559072,0.000249422,0.0002369175,0.0002887761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2941408,0.003552036,0.5941171,0.0007246418,0.004346723,0.0003111042,0.0003332842,0.001345682,0.009952193,0.00005913895,0.001113102,0.09000425],"study_design_scores_gemma":[0.008927042,0.05610644,0.9284515,0.00003986131,0.001454859,0.0005091302,0.0001022608,0.0008076501,0.002563825,0.0000375363,0.0009571004,0.00004285693],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975392,0.00166926,0.00008012768,0.00004576029,0.00000790834,0.00004038763,0.0003691796,0.00001052084,0.0002377127],"genre_scores_gemma":[0.9985685,0.0003744274,0.0001427388,0.00004232541,0.00002241594,0.00004103325,0.0006193322,0.000002850764,0.0001862741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003255334,"threshold_uncertainty_score":0.01721609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698217736784224,"score_gpt":0.2532701174016015,"score_spread":0.2262879400337593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}