{"id":"W2566171209","doi":"10.1038/nbt.3745","title":"Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker","year":2016,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":383,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; York University; University of Toronto; University Health Network","funders":"","keywords":"Sinoatrial node; Pacemaker potential; Induced pluripotent stem cell; Chronotropic; Cardiac pacemaker; Embryonic stem cell; Stem cell; Sick sinus syndrome; Internal medicine; Transplantation; Medicine; Biology; Cardiology; Cell biology; Heart rate; Electrophysiology; Blood pressure; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000388602,0.0002652961,0.0001768851,0.0001490677,0.0001576551,0.0004082384,0.0002748477,0.0003384232,0.001065485],"category_scores_gemma":[0.0002946819,0.0001582291,0.0002069441,0.0001044834,0.0004151343,0.0003011522,0.000247459,0.0004762988,0.0005596288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009653281,"about_ca_system_score_gemma":0.0001522159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004564013,"about_ca_topic_score_gemma":0.0001085093,"domain_scores_codex":[0.9998866,0.00003188802,0.00001218677,0.00002526311,0.00003191839,0.00001204941],"domain_scores_gemma":[0.9998124,0.00006909452,0.00002918034,0.00003357861,0.00002114408,0.00003466943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001105277,0.00001356141,0.0005510566,0.00004817812,0.00001154391,0.0001554844,0.00005551522,0.0001688653,0.9871002,0.004253986,0.000281197,0.007249919],"study_design_scores_gemma":[0.0001613495,0.0004978544,0.005161752,0.00002800157,0.00008941015,0.001105273,0.0001157902,0.003232299,0.9663756,0.003999686,0.01921508,0.00001786837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8764637,0.009882146,0.08850551,0.001264729,0.001952762,0.00007724465,0.0004294969,0.0006001957,0.02082425],"genre_scores_gemma":[0.9800387,0.002271849,0.01103099,0.000260222,0.0001981251,0.00002777271,0.00023204,0.00008641835,0.00585381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065485,"threshold_uncertainty_score":0.003564417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097610186426267,"score_gpt":0.2570651052491437,"score_spread":0.246089003384881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}