{"id":"W2566177767","doi":"10.15252/msb.20167381","title":"Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila","year":2016,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"Argonne National Laboratory; Biological and Environmental Research; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Canada Foundation for Innovation; Office of Extramural Research, National Institutes of Health; U.S. Department of Energy","keywords":"Effector; Legionella pneumophila; Biology; Cell biology; Secretion; Intracellular; Legionella; Intracellular parasite; Computational biology; Microbiology; Genetics; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003393078,0.0003163561,0.0003032216,0.0004802022,0.0001540439,0.0006064103,0.0001660549,0.000237609,0.0005533753],"category_scores_gemma":[0.0004532667,0.0001625591,0.0003731548,0.0004257038,0.0002183522,0.0002921835,0.0003039591,0.0002534919,0.0002542194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002339943,"about_ca_system_score_gemma":0.0001274855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002317752,"about_ca_topic_score_gemma":0.0005480698,"domain_scores_codex":[0.9997087,0.00003760043,0.00003898194,0.00007283369,0.0001101338,0.0000317972],"domain_scores_gemma":[0.9997604,0.00007858343,0.00006383922,0.00004420867,0.00002526305,0.00002758136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009551327,0.00002560971,0.01011174,0.0000577979,0.00002198482,0.00007603749,0.00002916176,0.0003458963,0.9853271,0.0001541453,0.00002510884,0.003729894],"study_design_scores_gemma":[0.0000144073,0.0004464384,0.1146097,0.00001932756,0.00008185019,0.001515925,0.0002002753,0.00448287,0.8757879,0.000373166,0.002444907,0.00002327335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956892,0.0007783287,0.002342032,0.00002593529,0.000003311306,0.00001388807,0.0004267449,0.00008769804,0.0006327069],"genre_scores_gemma":[0.9950321,0.0004145559,0.003162152,0.00002552876,0.000002653861,0.00001452107,0.0008300145,0.00001567501,0.0005028664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006064103,"threshold_uncertainty_score":0.001851201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577687059443217,"score_gpt":0.2630236494711083,"score_spread":0.2472467788766762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}