{"id":"W2566177767","doi":"10.15252/msb.20167381","title":"Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila","year":2016,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"Argonne National Laboratory; Biological and Environmental Research; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Canada Foundation for Innovation; Office of Extramural Research, National Institutes of Health; U.S. Department of Energy","keywords":"Effector; Legionella pneumophila; Biology; Cell biology; Secretion; Intracellular; Legionella; Intracellular parasite; Computational biology; Microbiology; Genetics; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005878879,0.0002520759,0.0004228835,0.0001543642,0.00004262229,0.00001648264,0.0003864281,0.0004194848,0.00001262737],"category_scores_gemma":[0.0000908267,0.0001812921,0.0001442066,0.0001403642,0.0001866983,0.00001079709,0.0002195879,0.0001014977,0.00001683255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003499896,"about_ca_system_score_gemma":0.00009458644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002257712,"about_ca_topic_score_gemma":0.00006860683,"domain_scores_codex":[0.9975787,0.0008173158,0.0003410188,0.0006373478,0.0001588393,0.0004667288],"domain_scores_gemma":[0.9989002,0.00002904728,0.0001653035,0.0006394348,0.000119704,0.0001463102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002707518,0.0001413596,0.00174633,0.00003887965,0.00006268096,0.00006568834,0.00001538443,0.000009955245,0.994189,0.001791355,0.00002602668,0.001642643],"study_design_scores_gemma":[0.001283616,0.000909131,0.0006976215,0.00003334102,0.00001659543,0.00002992953,0.00003155076,0.00005260091,0.9948606,0.000205513,0.001614997,0.0002644375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973632,0.0003439502,0.02472756,0.00009938816,0.00054326,0.0004686859,0.00009762193,0.00001376239,0.00007373373],"genre_scores_gemma":[0.9993307,0.00007195885,0.00009692364,0.00002500508,0.000192733,0.00006229587,0.00009037876,0.00003420755,0.00009577596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02569868,"threshold_uncertainty_score":0.7392877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577687059443217,"score_gpt":0.2630236494711083,"score_spread":0.2472467788766762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}