{"id":"W2566204996","doi":"10.1101/094540","title":"Genome-wide analysis of ivermectin response by <i>Onchocerca volvulus</i> reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Ivermectin; Biology; Onchocerca volvulus; Quantitative trait locus; Genetics; Onchocerciasis; Genetic diversity; Genetic variation; Genotyping; Genome; Population; Evolutionary biology; Gene; Genotype; Zoology; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001371704,0.0006057036,0.001832436,0.0008868627,0.0001034823,0.00004858938,0.0002252113,0.0003094742,0.00003789989],"category_scores_gemma":[0.001899494,0.0005407799,0.0004205676,0.001164024,0.0003370256,0.0000763244,0.0004329723,0.0003985934,0.00001499445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000590239,"about_ca_system_score_gemma":0.00112425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002116382,"about_ca_topic_score_gemma":0.00001399123,"domain_scores_codex":[0.9956142,0.000848532,0.0006967667,0.001203886,0.0008588149,0.0007778184],"domain_scores_gemma":[0.9945456,0.001117962,0.0005680358,0.001323636,0.001386444,0.001058275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002992628,0.0004316004,0.4679591,0.0003212632,0.005310236,0.0003326057,0.00003939191,0.00002983638,0.5221567,0.0000057994,0.000416777,0.000004067296],"study_design_scores_gemma":[0.001486124,0.0002610649,0.7464465,0.0004028929,0.002901616,7.255096e-8,0.000005205356,0.00006447233,0.2478286,0.000002103112,0.0002505452,0.0003508033],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866851,0.002169671,0.002521169,0.0005913686,0.00007915348,0.001661294,0.006203544,0.00008096989,0.000007723212],"genre_scores_gemma":[0.9984091,0.0004402563,0.0005997376,0.0002179386,0.00005719572,0.0001536376,0.000004233673,0.00007850382,0.00003938753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2784874,"threshold_uncertainty_score":0.9997044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008859858569164,"score_gpt":0.2522314434622535,"score_spread":0.2433715848930895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}