{"id":"W2566230668","doi":"10.1158/1538-7445.am2015-5333","title":"Abstract 5333: TH-302 potentiates the antitumor activity of topotecan in neuroblastoma and rhabdomyosarcoma preclinical models","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Topotecan; Rhabdomyosarcoma; Neuroblastoma; In vivo; Pharmacology; Medicine; Cytotoxicity; Tumor hypoxia; Hypoxia (environmental); Cancer research; Combination therapy; Cytotoxic T cell; Apoptosis; Cell culture; Chemotherapy; In vitro; Chemistry; Internal medicine; Pathology; Biology; Sarcoma; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217038,0.0004087809,0.0004327837,0.0002314162,0.0001105043,0.0001914187,0.0001847803,0.0002028515,0.002520482],"category_scores_gemma":[0.00005753017,0.00009434802,0.0002170793,0.0001625557,0.0001315122,0.0001291313,0.00009013046,0.0005574184,0.0004225301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002305151,"about_ca_system_score_gemma":0.0003513825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001636457,"about_ca_topic_score_gemma":0.003207846,"domain_scores_codex":[0.9999145,0.00001064482,0.000007703969,0.00001288558,0.00003111259,0.0000230918],"domain_scores_gemma":[0.9999505,0.000005830387,0.00001038492,0.000004620809,0.00000944288,0.0000192479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008326516,0.0003037166,0.0002085478,0.0001105499,0.00001682984,0.00006240118,0.00001212583,0.0002298267,0.9940691,0.00004000133,0.0002755802,0.003838765],"study_design_scores_gemma":[0.00009997879,0.004677116,0.003324036,0.000008793306,0.00003765394,0.0001778839,0.00001959698,0.0005708963,0.9894161,0.00001496223,0.001647272,0.000005664119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943644,0.001398867,0.0005395008,0.0000787941,0.00004062891,0.00006867309,0.0008648893,0.00009714391,0.002547068],"genre_scores_gemma":[0.9928237,0.001162775,0.000760027,0.00004613792,0.00001387018,0.0000541003,0.001305739,0.00001350238,0.003820072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002520482,"threshold_uncertainty_score":0.008431792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2409602749562205,"score_gpt":0.4650983606613697,"score_spread":0.2241380857051492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}