{"id":"W2566317011","doi":"10.1001/jamaoncol.2016.5478","title":"The <i>KRAS</i>-Variant and Cetuximab Response in Head and Neck Squamous Cell Cancer","year":2016,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute","keywords":"Cetuximab; KRAS; Medicine; Oncology; Internal medicine; Head and neck squamous-cell carcinoma; Head and neck cancer; Cancer; Colorectal cancer; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005346621,0.000110601,0.0003479917,0.00004918849,0.0001145744,0.00001056738,0.00004718107,0.0001300239,0.00003033756],"category_scores_gemma":[0.0003533338,0.00005594609,0.00002178066,0.00008580559,0.000237317,0.00004284616,0.00008358453,0.0001589318,0.000008743536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002013455,"about_ca_system_score_gemma":0.0003080012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003783089,"about_ca_topic_score_gemma":0.002492852,"domain_scores_codex":[0.9989824,0.0001862052,0.0002008801,0.0002366661,0.00008607933,0.0003078072],"domain_scores_gemma":[0.9983898,0.00124904,0.00005065913,0.0001611832,0.00004527156,0.0001040897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03928169,0.000590892,0.1188784,0.0001714208,0.00007108627,0.001584882,0.006024168,4.245085e-7,0.06807861,0.000615345,0.06333679,0.7013663],"study_design_scores_gemma":[0.01088783,0.002571269,0.3510733,0.0001002108,0.0000299194,0.0001457375,0.00026671,0.00001307405,0.0008331671,0.0001248886,0.6338577,0.00009613742],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8876798,0.00839635,0.000003797878,0.09817082,0.0002115098,0.0002211914,0.000009613099,0.00001686186,0.005290082],"genre_scores_gemma":[0.9881774,0.005741993,0.00009901523,0.003389878,0.000167236,0.00008771564,2.869353e-7,0.00001234607,0.002324199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7012702,"threshold_uncertainty_score":0.2281415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010996515376874,"score_gpt":0.3258279171779345,"score_spread":0.3057179520241658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}