{"id":"W2566438460","doi":"10.1212/wnl.86.16_supplement.p5.204","title":"Combination Therapy with Doxycycline, Chlorpromazine or Quinacrine Inhibits Prion Protein Replication in a N2A Model (P5.204)","year":2016,"lang":"en","type":"article","venue":"Neurology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Alberta Hospital; Alberta Hospital Edmonton","funders":"","keywords":"Doxycycline; Chlorpromazine; Prion protein; Replication (statistics); Virology; Pharmacology; Medicine; Biology; Internal medicine; Antibiotics; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003419321,0.001110047,0.0007646249,0.0007117962,0.0005090641,0.0004078403,0.0009012119,0.0009983197,0.002376829],"category_scores_gemma":[0.0001813323,0.0002461192,0.0007016206,0.0003313791,0.0005188353,0.0003823076,0.0002458156,0.001531367,0.001032863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000684548,"about_ca_system_score_gemma":0.0005644802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003884582,"about_ca_topic_score_gemma":0.007200469,"domain_scores_codex":[0.9996901,0.00004825902,0.00003081022,0.00007566434,0.00008377723,0.0000713531],"domain_scores_gemma":[0.9996666,0.00004469642,0.00008715595,0.00003470271,0.00002696268,0.0001399708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001350442,0.0008900051,0.0003005759,0.0001209864,0.00002897674,0.0005914904,0.00005050907,0.0002032654,0.9939214,0.00009710063,0.0005482702,0.001896916],"study_design_scores_gemma":[0.0003686564,0.01513232,0.005358043,0.0000502357,0.00009477745,0.00175591,0.00009826418,0.002167511,0.9690762,0.0001051904,0.005763381,0.00002962411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910067,0.002119148,0.001077835,0.0002906332,0.0001512615,0.0001979668,0.001704204,0.0002104132,0.003241942],"genre_scores_gemma":[0.9832271,0.002323285,0.003951695,0.000131971,0.00005270589,0.000434286,0.002305273,0.00005016633,0.00752335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003884582,"threshold_uncertainty_score":0.00795126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540694606431864,"score_gpt":0.2607151094611643,"score_spread":0.2453081633968457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}