{"id":"W2566463587","doi":"10.1158/1538-7445.am2015-2508","title":"Abstract 2508: Multi-modal treatment with peptide vaccine, metronomic cyclophosphamide and anti-PD1 monoclonal antibody provides effective control of tumors in multiple models","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Immunovaccine (Canada)","funders":"","keywords":"Medicine; ELISPOT; Ovarian cancer; Immunogenicity; Immune system; Cancer research; Cyclophosphamide; CD8; Cytotoxic T cell; Cancer vaccine; Tumor microenvironment; Immunology; Cancer; Combination therapy; Immunotherapy; Pharmacology; Chemotherapy; Internal medicine; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311312,0.0005086661,0.0004143376,0.0002431012,0.0001183015,0.0002451803,0.0002671013,0.0003571371,0.001725969],"category_scores_gemma":[0.00005915487,0.0001291347,0.0002533623,0.0001318216,0.0001702312,0.0002302747,0.0001873085,0.0009058866,0.0003192995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00024337,"about_ca_system_score_gemma":0.0002889401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003684581,"about_ca_topic_score_gemma":0.0005877729,"domain_scores_codex":[0.9998835,0.00001456067,0.000007910645,0.00003054277,0.00002691812,0.00003659959],"domain_scores_gemma":[0.9999462,0.000005553774,0.00001342322,0.000007069892,0.000005479395,0.00002220294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001060479,0.0006466717,0.0001892533,0.000080413,0.00001689916,0.00003356002,0.00001256686,0.0002592584,0.9900907,0.0001275554,0.0003196673,0.007163029],"study_design_scores_gemma":[0.0003279031,0.01065891,0.002052088,0.00001130332,0.00005354939,0.000354869,0.00001311404,0.001832898,0.9803325,0.00006219669,0.004294557,0.000006114351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928993,0.001457649,0.002878023,0.0001439321,0.0001237121,0.0001384427,0.000399293,0.0001505592,0.001809014],"genre_scores_gemma":[0.9929254,0.0005420797,0.002645418,0.00005200083,0.00002895494,0.0001411677,0.0003909001,0.00001956105,0.003254418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001725969,"threshold_uncertainty_score":0.005773962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04498884170959708,"score_gpt":0.3446947686963435,"score_spread":0.2997059269867464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}