{"id":"W2566482839","doi":"10.1093/neuonc/nov215.25","title":"GENO-25HYPERMUTATION AND MALIGNANT PROGRESSION IN AN EXPANDED COHORT OF TEMOZOLOMIDE-TREATED LOW-GRADE GLIOMA PATIENTS","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Temozolomide; Somatic hypermutation; Oncology; Medicine; Exome sequencing; Glioma; Cancer research; Cohort; Internal medicine; Mutation; Frameshift mutation; IDH1; DNA mismatch repair; Biology; Gene; Genetics; Cancer; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088945,0.0001859995,0.000288906,0.0003794518,0.0002328502,0.0003093861,0.000154481,0.0001565327,0.0008022166],"category_scores_gemma":[0.0003647091,0.0001147655,0.000172163,0.0002775664,0.000132348,0.0001835368,0.0002606632,0.0002858489,0.0001469121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001749074,"about_ca_system_score_gemma":0.0001205157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001979863,"about_ca_topic_score_gemma":0.002956872,"domain_scores_codex":[0.9999243,0.000009047282,0.000006281876,0.00003094172,0.00001464997,0.00001478132],"domain_scores_gemma":[0.9998395,0.00001775753,0.00004517813,0.00001757249,0.00001755239,0.00006237401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008257105,0.0001151243,0.9805234,0.0000100346,0.000064832,0.001129531,0.0002521103,0.0001417945,0.008456139,0.00002164834,0.0002526408,0.008207037],"study_design_scores_gemma":[0.00001501846,0.0003237974,0.99657,0.0000026114,0.00003242156,0.001879704,0.0001065308,0.0002395956,0.000427713,0.00001612217,0.0003822373,0.00000419448],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997757,0.00004692588,0.00001290209,0.000006914363,6.822865e-7,0.00000232949,0.00007010671,0.000001340283,0.00008312622],"genre_scores_gemma":[0.9994668,0.00006188401,0.00003117248,0.00001706896,0.000003735348,0.000003280824,0.0003046831,0.000001496921,0.0001098068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001979863,"threshold_uncertainty_score":0.003936708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0279153896075524,"score_gpt":0.3266087347027697,"score_spread":0.2986933450952173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}