{"id":"W2566580306","doi":"10.1074/jbc.m116.769430","title":"The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Université de Sherbrooke; McGill University","funders":"Canadian Institutes of Health Research; Canada Excellence Research Chairs, Government of Canada; Fondation Leducq; University of Pennsylvania; Pfizer","keywords":"LDL receptor; PCSK9; Familial hypercholesterolemia; Kexin; Proprotein convertase; Internalization; Endosome; Low-density lipoprotein; Lipoprotein; Chemistry; Cholesterol; Endocrinology; Internal medicine; Receptor; Biology; Cell biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022381,0.0004164002,0.0002549897,0.0002442307,0.0001771742,0.0001713992,0.0001839092,0.0004945648,0.0007078191],"category_scores_gemma":[0.0002461199,0.0001186887,0.000339882,0.0001415569,0.0001958793,0.00007224207,0.000205022,0.000316852,0.0004074111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001733614,"about_ca_system_score_gemma":0.000151358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007163153,"about_ca_topic_score_gemma":0.0005257494,"domain_scores_codex":[0.999884,0.00001792477,0.0000138273,0.0000301396,0.00003897532,0.00001509187],"domain_scores_gemma":[0.9999424,0.00001625631,0.00001893211,0.000004796126,0.000004938843,0.00001272499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005759921,0.0001016138,0.01235986,0.0001077345,0.00007695297,0.05750611,0.0001356079,0.001147664,0.909043,0.0007650708,0.0006228229,0.01755764],"study_design_scores_gemma":[0.0001903515,0.001434465,0.08077698,0.00004079321,0.0001739386,0.3355829,0.000169676,0.01764606,0.5478778,0.0007314259,0.01527179,0.00010382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995307,0.0004753277,0.002630671,0.0001117622,0.00002953039,0.00002726283,0.0002804113,0.00007556011,0.001062332],"genre_scores_gemma":[0.9962941,0.0002397182,0.002280506,0.00003579355,0.00001081146,0.000007757852,0.0002743496,0.00001310532,0.0008439751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007163153,"threshold_uncertainty_score":0.002367854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751993100563607,"score_gpt":0.2510005427700183,"score_spread":0.2334806117643823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}