{"id":"W2566627348","doi":"10.3390/toxins9010007","title":"A Novel Toxin from Haplopelma lividum Selectively Inhibits the NaV1.8 Channel and Possesses Potent Analgesic Efficacy","year":2016,"lang":"en","type":"article","venue":"Toxins","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Youth Innovation Promotion Association; Novo Nordisk Fonden; Novo Nordisk; National Natural Science Foundation of China; Canadian Anesthesiologists' Society","keywords":"Pharmacology; Sodium channel; Analgesic; Licking; Chemistry; Venom; Neuropathic pain; Morphine; Spider toxin; IC50; Sodium; In vitro; Receptor; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141201,0.0001495768,0.0001062051,0.00003617531,0.0001420011,0.00003499208,0.0001062989,0.0001175605,0.00003414107],"category_scores_gemma":[0.0001224976,0.00008775336,0.00005608021,0.0001015429,0.00008576214,0.000008938107,0.00009144798,0.00005521799,0.00002534502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001720665,"about_ca_system_score_gemma":0.00004585521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004570381,"about_ca_topic_score_gemma":0.0000703981,"domain_scores_codex":[0.999159,0.00004236091,0.0001441752,0.000332716,0.0001250404,0.0001966851],"domain_scores_gemma":[0.9995091,0.00004313959,0.00006902921,0.0002113356,0.00009144835,0.00007593297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001305014,0.0001114202,0.0002194202,0.000004072532,0.00006465215,7.960283e-7,0.000158163,0.00002476013,0.9870763,0.0001727734,0.002308358,0.009728718],"study_design_scores_gemma":[0.002418978,0.0004854466,0.09021016,0.00007454699,0.00004509753,0.00003865162,0.0001984316,0.0003582618,0.8723221,0.0002546059,0.03318761,0.0004061312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757718,0.0004318715,0.02022764,0.002483943,0.000287193,0.0002072137,0.00006207888,0.00002956369,0.0004986971],"genre_scores_gemma":[0.996533,0.0001979719,0.0001139532,0.0005566365,0.0006303681,0.00001669235,0.00003914419,0.00002082118,0.001891454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1147543,"threshold_uncertainty_score":0.3578478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01795368611825816,"score_gpt":0.2334717194100717,"score_spread":0.2155180332918135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}