{"id":"W2566627348","doi":"10.3390/toxins9010007","title":"A Novel Toxin from Haplopelma lividum Selectively Inhibits the NaV1.8 Channel and Possesses Potent Analgesic Efficacy","year":2016,"lang":"en","type":"article","venue":"Toxins","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Youth Innovation Promotion Association; Novo Nordisk Fonden; Novo Nordisk; National Natural Science Foundation of China; Canadian Anesthesiologists' Society","keywords":"Pharmacology; Sodium channel; Analgesic; Licking; Chemistry; Venom; Neuropathic pain; Morphine; Spider toxin; IC50; Sodium; In vitro; Receptor; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005474165,0.0002235653,0.0002917609,0.0001441764,0.00009033283,0.0001310359,0.0001256322,0.0001852863,0.0004962242],"category_scores_gemma":[0.00005890724,0.00005200376,0.0001620602,0.0001014164,0.0001355112,0.0001317763,0.000133759,0.0002809198,0.0001217287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001339976,"about_ca_system_score_gemma":0.000116048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002118942,"about_ca_topic_score_gemma":0.0002649717,"domain_scores_codex":[0.9999624,0.000004428704,0.000003838855,0.000007955954,0.00001127744,0.00001007311],"domain_scores_gemma":[0.9999714,0.000003534056,0.000009351059,0.000001983261,0.000004182973,0.000009633605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004940881,0.00001160847,0.0002034763,0.00003691638,0.000003389598,0.0000610487,0.000004588094,0.00003316031,0.9981771,0.00002385452,0.00001270793,0.001382945],"study_design_scores_gemma":[0.00007613096,0.00155608,0.01636925,0.00001509478,0.00004447185,0.001449721,0.00003222238,0.001227322,0.9757612,0.00005795865,0.003401597,0.00000903603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949266,0.002395487,0.001753724,0.00006456992,0.00001589802,0.00002259431,0.0001225415,0.0000416435,0.0006569427],"genre_scores_gemma":[0.995272,0.001116315,0.001993727,0.00004499349,0.00001067023,0.000017617,0.0004105878,0.000006352847,0.001127681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004962242,"threshold_uncertainty_score":0.001660109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01795368611825816,"score_gpt":0.2334717194100717,"score_spread":0.2155180332918135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}