{"id":"W2566676181","doi":"10.1021/acssynbio.6b00125","title":"Design and Experimental Validation of Small Activating RNAs Targeting an Exogenous Promoter in Human Cells","year":2016,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Computational biology; RNA; Promoter; RNA interference; Biology; Gene; Synthetic biology; Reporter gene; Mechanism (biology); Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002782286,0.0006568632,0.0006612792,0.0003352325,0.0004233218,0.0006581459,0.0006625648,0.0006575377,0.001658559],"category_scores_gemma":[0.001302103,0.00040528,0.0004880625,0.0003671007,0.0005745224,0.0002449329,0.0004897758,0.0008019109,0.0007964559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004889707,"about_ca_system_score_gemma":0.001119844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006708337,"about_ca_topic_score_gemma":0.001023742,"domain_scores_codex":[0.998381,0.0005781996,0.0001656909,0.0003019318,0.0004358092,0.0001373224],"domain_scores_gemma":[0.9992027,0.0003364974,0.00009823753,0.0001320547,0.0001482122,0.00008232661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002124962,0.0001526357,0.0002087432,0.00009813585,0.000007983499,0.0001031517,0.00008560631,0.001543409,0.9942163,0.0004515459,0.00007431394,0.002845607],"study_design_scores_gemma":[0.0000434422,0.0009510252,0.0002683137,0.000006200413,0.0000155608,0.00006593218,0.0000258424,0.001490069,0.9945254,0.00004694924,0.002553506,0.000007920291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8122528,0.0009386842,0.175894,0.0002151577,0.0001141497,0.005134292,0.001150978,0.0006596835,0.003640274],"genre_scores_gemma":[0.7359686,0.001486514,0.2496201,0.0001675827,0.00004915265,0.005074544,0.002150841,0.0002236117,0.005259198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002782286,"threshold_uncertainty_score":0.0147143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02447735631831132,"score_gpt":0.2596013579485293,"score_spread":0.235124001630218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}