{"id":"W2566676181","doi":"10.1021/acssynbio.6b00125","title":"Design and Experimental Validation of Small Activating RNAs Targeting an Exogenous Promoter in Human Cells","year":2016,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Computational biology; RNA; Promoter; RNA interference; Biology; Gene; Synthetic biology; Reporter gene; Mechanism (biology); Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004724336,0.0001349914,0.000166696,0.00004933896,0.0000600597,0.000006859129,0.0001396496,0.0001993224,0.00002848473],"category_scores_gemma":[0.00006029238,0.00009936325,0.00002531357,0.00002920001,0.0001118072,0.000005758689,0.00007898238,0.00003547619,0.000001638871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001074286,"about_ca_system_score_gemma":0.00001953679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002396711,"about_ca_topic_score_gemma":0.000001826357,"domain_scores_codex":[0.9988035,0.0003496748,0.0002457115,0.000344482,0.00003814003,0.0002185067],"domain_scores_gemma":[0.9995375,0.00005180973,0.0001315443,0.0002102798,0.00002711007,0.00004180789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000508792,0.00006944377,0.0002164217,0.000007353647,0.00001053375,9.297524e-7,0.0001777898,0.000006792098,0.9885261,0.00007563881,0.000001499751,0.01085664],"study_design_scores_gemma":[0.0003208068,0.0007485661,0.00003017383,0.00003180254,0.000004002957,0.000007795603,0.00009414436,0.000007376542,0.9978841,0.0005945266,0.0001345539,0.0001421667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732202,0.0002415456,0.02610759,0.00004289198,0.00005312964,0.0002666536,0.000003433089,0.00000768796,0.00005687992],"genre_scores_gemma":[0.9909118,0.00002980022,0.008882307,0.00002195979,0.00005108676,0.00004094277,0.00001025751,0.00001971998,0.00003209071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01769164,"threshold_uncertainty_score":0.4051916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02447735631831132,"score_gpt":0.2596013579485293,"score_spread":0.235124001630218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}