{"id":"W2566701865","doi":"10.1016/j.dadm.2016.12.007","title":"Alzheimer's disease: The influence of age on clinical heterogeneity through the human brain connectome","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Norman Cousins Center for Psychoneuroimmunology; National Institute on Deafness and Other Communication Disorders; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; Takeda Pharmaceutical Company; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; AbbVie; Merck; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Atrophy; Dementia; Neuroscience; Neuropathology; Psychology; Clinical Dementia Rating; Posterior cingulate; Context (archaeology); Early-onset Alzheimer's disease; Temporal lobe; Posterior cortical atrophy; Neuroimaging; Alzheimer's disease; Disease; Cortex (anatomy); Cognition; Medicine; Pathology; Cognitive impairment; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001097028,0.0005542617,0.0005004515,0.00008391056,0.00134443,0.0001884223,0.001292725,0.0000730434,0.00007441638],"category_scores_gemma":[0.003851872,0.0003114043,0.0005531067,0.0004178936,0.001086418,0.0006739568,0.000798477,0.0003618125,0.00006071022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005860293,"about_ca_system_score_gemma":0.0001671856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009818508,"about_ca_topic_score_gemma":0.00001618384,"domain_scores_codex":[0.9940345,0.001455221,0.0009752601,0.001322752,0.001479043,0.0007332524],"domain_scores_gemma":[0.9764082,0.02087091,0.0005754806,0.001630066,0.0001554134,0.0003599396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000128127,0.001217391,0.9718459,0.00001375241,0.003210447,0.00008295619,0.00008715595,0.0005666644,0.00667708,0.006906769,0.004945696,0.00431809],"study_design_scores_gemma":[0.0008312555,0.0002247808,0.9630387,0.000230596,0.003381642,6.420108e-7,0.00004658243,0.000009834066,0.02133674,0.002025922,0.008446689,0.0004265492],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660085,0.006404771,0.00004634228,0.02441438,0.001381347,0.001273283,0.0001784094,0.0001511777,0.0001417771],"genre_scores_gemma":[0.9927822,0.0007788886,0.0000470447,0.004026737,0.0006905199,0.001594351,0.000004949323,0.0000678981,0.000007396311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0267737,"threshold_uncertainty_score":0.9999557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1205720852054709,"score_gpt":0.4014169695449027,"score_spread":0.2808448843394319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}