{"id":"W2566701865","doi":"10.1016/j.dadm.2016.12.007","title":"Alzheimer's disease: The influence of age on clinical heterogeneity through the human brain connectome","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Norman Cousins Center for Psychoneuroimmunology; National Institute on Deafness and Other Communication Disorders; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; Takeda Pharmaceutical Company; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; AbbVie; Merck; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Atrophy; Dementia; Neuroscience; Neuropathology; Psychology; Clinical Dementia Rating; Posterior cingulate; Context (archaeology); Early-onset Alzheimer's disease; Temporal lobe; Posterior cortical atrophy; Neuroimaging; Alzheimer's disease; Disease; Cortex (anatomy); Cognition; Medicine; Pathology; Cognitive impairment; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005064245,0.000157761,0.0002188101,0.0008146833,0.0001698977,0.000450186,0.0001295269,0.0001940405,0.0008658709],"category_scores_gemma":[0.001518553,0.00008188168,0.0001413661,0.0005479938,0.0003357721,0.0006281682,0.0003236111,0.0001614439,0.00007501958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001514031,"about_ca_system_score_gemma":0.0001106186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001323165,"about_ca_topic_score_gemma":0.002804816,"domain_scores_codex":[0.9998425,0.0000629648,0.0000115149,0.00003973606,0.00002880185,0.00001435022],"domain_scores_gemma":[0.999456,0.0002067986,0.0002004328,0.00005476211,0.00003351962,0.00004861287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003836839,0.00002930522,0.9560005,0.00006883428,0.0003209331,0.0007132476,0.0005048245,0.0007760692,0.01263726,0.0008378814,0.0003999787,0.02732745],"study_design_scores_gemma":[0.000002330739,0.00002351815,0.9979639,0.000006086619,0.00001870564,0.0004013137,0.00006023978,0.0003354086,0.0001874951,0.0007979477,0.000200301,0.000002787901],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956869,0.002215403,0.000697992,0.0001619008,0.000006537546,0.00000772365,0.0002401584,0.00000502393,0.0009782688],"genre_scores_gemma":[0.9993384,0.0003146137,0.0001693879,0.00001813008,0.00001479584,0.000003004029,0.00007855229,0.000001569827,0.00006159381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323165,"threshold_uncertainty_score":0.002896667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1205720852054709,"score_gpt":0.4014169695449027,"score_spread":0.2808448843394319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}