{"id":"W2566718115","doi":"10.1182/blood.v106.11.238.238","title":"The First Fully Experimental In Vivo Model of Human Leukemogenesis: Human Hematopoietic Stem Cells Infected with MLL-ENL Induce Pro-B Acute Lymphoblastic Leukemia in NOD/SCID Mice.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Haematopoiesis; Leukemia; Myeloid; Bone marrow; Severe combined immunodeficiency; Progenitor cell; Immunology; Stem cell; Acute lymphocytic leukemia; Cancer research; Transplantation; CD19; Molecular biology; Antigen; In vivo; Medicine; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006584464,0.0009398476,0.0004388725,0.0005620176,0.0003637298,0.0005881495,0.000498881,0.0007827966,0.004324433],"category_scores_gemma":[0.0001127991,0.0003258515,0.0004081824,0.0002795529,0.0005676787,0.0003504252,0.0003669526,0.002079085,0.001031519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003612427,"about_ca_system_score_gemma":0.0003001141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003927175,"about_ca_topic_score_gemma":0.0005627751,"domain_scores_codex":[0.9995332,0.0001535919,0.00004821575,0.00008702399,0.0001096799,0.00006839136],"domain_scores_gemma":[0.9997963,0.00003022893,0.00004216215,0.00005828384,0.00001213344,0.0000608781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005090764,0.0007040838,0.0002542197,0.00008374884,0.00001546147,0.000118835,0.00005184441,0.0001372468,0.9955739,0.0006074739,0.0002525911,0.001691689],"study_design_scores_gemma":[0.000143979,0.003297364,0.001262274,0.00001676219,0.00002687788,0.0004595129,0.00003118537,0.0007307116,0.9849935,0.0001380487,0.008894379,0.000005496225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514039,0.003573591,0.02814256,0.0007096094,0.0002749449,0.001424979,0.0050575,0.0007815107,0.008631396],"genre_scores_gemma":[0.9620234,0.002042185,0.01724947,0.0002444583,0.0000505189,0.001266226,0.004727964,0.00009519875,0.01230062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004324433,"threshold_uncertainty_score":0.0144667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01860360265940068,"score_gpt":0.2674211626186581,"score_spread":0.2488175599592574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}