{"id":"W2566735365","doi":"10.1158/1538-7445.am2015-4533","title":"Abstract 4533: New antimicrotubule phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonate prodrugs bioactivated selectively in breast cancer cells by CYP1A1: An innovative approach for the personalized treatment of breast cancer","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Prodrug; Breast cancer; Cancer research; Cancer; Moiety; Chemistry; Triple-negative breast cancer; Cancer cell; In vivo; Medicine; Pharmacology; Stereochemistry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005210574,0.0004351357,0.0005408081,0.0001262272,0.000315821,0.000100889,0.0007147072,0.0002575481,0.0008884082],"category_scores_gemma":[0.0000296681,0.0003355227,0.0001184336,0.001722867,0.0004981875,0.0002707089,0.00009545895,0.0005397404,0.000003546862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001978782,"about_ca_system_score_gemma":0.003149748,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02389646,"about_ca_topic_score_gemma":0.0005061868,"domain_scores_codex":[0.9967694,0.00007139971,0.0005323614,0.0009651267,0.0006886442,0.0009730881],"domain_scores_gemma":[0.9968523,0.000282632,0.0002839173,0.0006278292,0.001573257,0.0003800728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001713307,0.001290715,0.002162176,0.000244762,0.0003163667,0.000001705102,0.002890656,0.0004047757,0.9689585,0.00005210437,0.007912202,0.01405276],"study_design_scores_gemma":[0.004140675,0.00003985758,0.001430769,0.0001264126,0.00004328358,0.00001039729,0.002524092,0.0007047747,0.9801261,0.00006250486,0.01039508,0.0003960262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827225,0.002079763,0.00005461458,0.004172715,0.00004558031,0.001377327,0.00833142,0.00006253054,0.001153579],"genre_scores_gemma":[0.9902249,0.001479187,0.000109883,0.0000479928,0.0005409056,0.004580273,0.0003125607,0.00009334918,0.00261096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02339028,"threshold_uncertainty_score":0.9999097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1063179295953464,"score_gpt":0.3923233995681608,"score_spread":0.2860054699728143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}