{"id":"W2566735365","doi":"10.1158/1538-7445.am2015-4533","title":"Abstract 4533: New antimicrotubule phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonate prodrugs bioactivated selectively in breast cancer cells by CYP1A1: An innovative approach for the personalized treatment of breast cancer","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Prodrug; Breast cancer; Cancer research; Cancer; Moiety; Chemistry; Triple-negative breast cancer; Cancer cell; In vivo; Medicine; Pharmacology; Stereochemistry; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009199529,0.0003037789,0.0001757219,0.0001613998,0.00006437471,0.0001152377,0.0001513467,0.0002354665,0.001279727],"category_scores_gemma":[0.00005227814,0.00009777254,0.0001760391,0.0001314241,0.00009172734,0.0001087276,0.0001064325,0.0003443404,0.0004942154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000144186,"about_ca_system_score_gemma":0.0002048307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003674398,"about_ca_topic_score_gemma":0.0006094563,"domain_scores_codex":[0.9999617,0.000007060084,0.000002938002,0.000008586498,0.00000944513,0.00001026135],"domain_scores_gemma":[0.9999797,0.000002012098,0.000005991089,0.000001884996,0.000003985745,0.000006454626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001645822,0.000108784,0.0001815482,0.0001372769,0.00001016284,0.0001210081,0.00002539862,0.0004092606,0.9814914,0.000578152,0.0005326043,0.01623975],"study_design_scores_gemma":[0.0002829937,0.005085559,0.003892076,0.00002630803,0.00004663518,0.0006501431,0.00001776688,0.002504258,0.9668928,0.0001212612,0.02046083,0.00001937466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650609,0.0111668,0.01503603,0.0003681826,0.0001463926,0.0002606479,0.0007036363,0.0003136491,0.006943754],"genre_scores_gemma":[0.9774024,0.004534553,0.01092256,0.0002366914,0.00003010431,0.0001228587,0.0007826954,0.00002426113,0.005943976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279727,"threshold_uncertainty_score":0.004281163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1063179295953464,"score_gpt":0.3923233995681608,"score_spread":0.2860054699728143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}