{"id":"W2566827455","doi":"10.1016/s1525-0016(16)34097-7","title":"488. Development of a Robust Non-Viral Gene Delivery System for Gut Mucosal Cells","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Gene delivery; Genetic enhancement; Immune system; Transfection; Colitis; In vivo; Chemistry; Glucosamine; Molecular biology; Pharmacology; Biology; Gene; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217128,0.0002043882,0.0002200586,0.00005535006,0.00004774944,0.00001833098,0.0002901441,0.0001571584,0.000003383551],"category_scores_gemma":[0.000008212435,0.0001902998,0.0001397292,0.00006196024,0.00004024101,0.000004336114,0.00006887766,0.00004677908,0.00001847448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003305414,"about_ca_system_score_gemma":0.0002951108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001928083,"about_ca_topic_score_gemma":0.000006671602,"domain_scores_codex":[0.9988601,0.00004230828,0.0003141884,0.0003395726,0.0001746627,0.0002691222],"domain_scores_gemma":[0.9991021,0.000004632553,0.0001153877,0.0003579217,0.0003108518,0.0001091043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003908514,0.00007235835,0.00005330136,0.00002787595,0.0001575095,0.000007660277,0.0001599366,0.0005662931,0.992393,0.00001094273,0.001033071,0.005127247],"study_design_scores_gemma":[0.001429989,0.0005569354,0.000109242,0.00002108189,0.00001340693,0.00000817599,0.0001677921,0.0002328967,0.9886925,0.000009322847,0.008526757,0.0002319533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9283941,0.001398577,0.06929209,0.00001703631,0.0002632634,0.0003561258,0.00002278451,0.00001279132,0.0002432643],"genre_scores_gemma":[0.9840109,0.00006769436,0.01508781,0.0001929949,0.0001130649,0.00008175504,0.0001539014,0.00003770637,0.0002541954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05561681,"threshold_uncertainty_score":0.77602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02593423967145266,"score_gpt":0.2419500804809475,"score_spread":0.2160158408094948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}