{"id":"W2566864507","doi":"10.1158/1538-7445.am2015-524","title":"Abstract 524: Assessing the interaction between acetylenic tricyclic bis-(cyano enone) and cysteine residues of actin to inhibit non-small cell lung cancer cell migration","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Actin; Cell migration; Actin cytoskeleton; Cell biology; Cytoskeleton; MDia1; Actin-binding protein; Lamellipodium; Actin remodeling; Chemistry; Cell; A549 cell; Stress fiber; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529234,0.0002754563,0.0002337566,0.000141141,0.0001170227,0.0001017507,0.0001684641,0.0002349702,0.001388074],"category_scores_gemma":[0.000115446,0.00009825687,0.0001757608,0.0001543875,0.0001069587,0.00008355809,0.00009397027,0.000235637,0.0002387408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001650634,"about_ca_system_score_gemma":0.000132495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006750587,"about_ca_topic_score_gemma":0.0009770334,"domain_scores_codex":[0.999886,0.00003091611,0.000009810584,0.00001774239,0.00003331578,0.00002219037],"domain_scores_gemma":[0.9999102,0.00002269385,0.00002081678,0.000008863735,0.00001725744,0.00002001335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001136987,0.00002984539,0.00006870737,0.00002951778,0.000005053837,0.00001294471,0.000003566829,0.0000588658,0.9990804,0.00001043352,0.00001737185,0.0005695941],"study_design_scores_gemma":[0.00001420133,0.0004803673,0.001294141,0.00000271004,0.00001160419,0.00004169208,0.000005519552,0.0007290226,0.9967088,0.000004358109,0.0007057,0.000001796726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961349,0.001422001,0.001287093,0.00003967761,0.00001846712,0.00004071247,0.000192597,0.00002420358,0.0008402852],"genre_scores_gemma":[0.9935028,0.0007890453,0.002640864,0.00004622649,0.000005235588,0.00004924948,0.0005626413,0.00001274461,0.002391241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001388074,"threshold_uncertainty_score":0.004643559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1425801760574647,"score_gpt":0.4768796802546522,"score_spread":0.3342995041971876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}