{"id":"W2566902031","doi":"10.1016/j.nano.2016.12.014","title":"Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA","year":2016,"lang":"en","type":"article","venue":"Nanomedicine Nanotechnology Biology and Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Transfection; Lipofectamine; HeLa; In vivo; In vitro; Chemistry; Gene delivery; Reporter gene; Cell biology; Plasmid; Microinjection; Cell culture; Molecular biology; DNA; Biology; Biochemistry; Gene; Gene expression; Recombinant DNA; Vector (molecular biology); Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002511564,0.000311736,0.0001844454,0.0001823574,0.0002137434,0.0003096203,0.0002324875,0.0003873836,0.0005159963],"category_scores_gemma":[0.0002046678,0.0003107222,0.0002815827,0.00009277592,0.0001941195,0.0002378719,0.0002274756,0.0003279427,0.0003447809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006210355,"about_ca_system_score_gemma":0.0003866848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006013614,"about_ca_topic_score_gemma":0.0009687598,"domain_scores_codex":[0.9998988,0.00001762595,0.00001059636,0.00002213666,0.00002819354,0.00002252439],"domain_scores_gemma":[0.9999251,0.00001607648,0.00002197847,0.000006344787,0.00001729109,0.00001318768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006639257,0.00001771324,0.00005354656,0.00003828531,0.000004442162,0.00003045996,0.00001710465,0.0006289871,0.9972745,0.0004294841,0.00002830535,0.001410966],"study_design_scores_gemma":[0.00001249431,0.00005635907,0.00007771731,0.000001842207,0.000005383837,0.00002731519,0.000004241953,0.001572554,0.996999,0.00005273608,0.001187248,0.000003156256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8989692,0.001305337,0.09481759,0.0003350319,0.00007143978,0.0002949313,0.0002655003,0.0002460498,0.003694883],"genre_scores_gemma":[0.9514263,0.0008064079,0.04217048,0.0001086793,0.000007657456,0.0002104174,0.000259362,0.00006008162,0.004950496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006210355,"threshold_uncertainty_score":0.004505932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336269020109376,"score_gpt":0.2590807371531895,"score_spread":0.2457180469520957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}