{"id":"W2566910492","doi":"10.1038/srep39519","title":"NF-κB signalling and cell fate decisions in response to a short pulse of tumour necrosis factor","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Fonds Québécois de la Recherche sur la Nature et les Technologies; Faculty of Medicine, McGill University; McGill University","keywords":"Tumor necrosis factor alpha; HeLa; Apoptosis; Cytokine; Necrosis; Cancer research; Programmed cell death; Cell biology; Cell fate determination; Cell; NF-κB; Signal transduction; Biology; Transcription factor; Chemistry; Medicine; Immunology; Gene; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001609294,0.0001435604,0.0001842434,0.0002043973,0.00008709052,0.00006198965,0.000149327,0.00009942772,0.00002909674],"category_scores_gemma":[0.0008894009,0.0001090367,0.00007451673,0.0002670651,0.0001383318,0.000008004187,0.0001900516,0.00004859007,0.00000645011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000218859,"about_ca_system_score_gemma":0.0001771542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002000109,"about_ca_topic_score_gemma":0.00005158471,"domain_scores_codex":[0.9980401,0.00008775884,0.0005009226,0.000778046,0.000294159,0.0002990162],"domain_scores_gemma":[0.9988454,0.00007524727,0.0001275295,0.0006133704,0.0001596199,0.0001788227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001460767,0.00004614735,0.006920746,0.000004886387,0.000004880113,0.00008938077,0.0001362981,0.00003768834,0.9903475,8.069393e-7,0.0005845182,0.001681092],"study_design_scores_gemma":[0.0001467359,0.0001052053,0.005215465,0.00008461761,0.000005558877,0.00003495383,0.00002751482,0.000006579662,0.9892745,0.0002312651,0.004712554,0.0001550269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969611,0.0001561971,0.001836487,0.00008540042,0.0005903238,0.0002367233,0.00002443611,0.000009545532,0.00009985226],"genre_scores_gemma":[0.9971576,0.00001236835,0.001088447,0.00002174966,0.00002367023,0.0000163197,0.00001079493,0.00001882894,0.001650194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004128036,"threshold_uncertainty_score":0.4446386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119212720633755,"score_gpt":0.2618557560538222,"score_spread":0.2406636288474846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}