{"id":"W2566999893","doi":"10.2147/dddt.s123386","title":"Folic acid-conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform","year":2016,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Royal Military College of Canada","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Amphiphile; Drug delivery; Chemistry; Biophysics; Conjugated system; Cancer cell; Internalization; Targeted drug delivery; Copolymer; SMA*; Biochemistry; Combinatorial chemistry; Cell; Polymer; Cancer; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001002947,0.0004466945,0.0004040086,0.0001906831,0.0004396856,0.0001865778,0.0004120042,0.00006393787,0.0007578704],"category_scores_gemma":[0.0001115984,0.000318682,0.00006736851,0.0002515583,0.0001410523,0.0008469732,0.0001268433,0.0001198256,0.0006572027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001984735,"about_ca_system_score_gemma":0.0008057833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002997025,"about_ca_topic_score_gemma":0.0000152321,"domain_scores_codex":[0.997116,0.0001757134,0.0006005376,0.0007130658,0.0005273516,0.0008673202],"domain_scores_gemma":[0.9983898,0.0004610263,0.000306015,0.0002725563,0.0001241717,0.0004463782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006314385,0.00006789887,0.0003365073,0.000007355046,0.00005829643,0.00004394411,0.003637819,0.00000387327,0.9168429,0.0001053603,0.001392806,0.07687178],"study_design_scores_gemma":[0.002920676,0.00005847003,0.0001221915,0.0001319311,0.00001119541,0.00001604027,0.0002940134,0.00005960227,0.9907604,0.001307683,0.003766948,0.0005508024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944474,0.002073384,0.001439875,0.0007466031,0.0003085341,0.0005987943,0.000007056027,0.0002760983,0.0001022869],"genre_scores_gemma":[0.9903334,0.0003152635,0.006878172,0.001193001,0.0001841676,0.00008500915,0.000006997796,0.00006674333,0.0009372763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07632098,"threshold_uncertainty_score":0.9999265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02232719053644754,"score_gpt":0.2342142989801558,"score_spread":0.2118871084437082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}