{"id":"W2567191481","doi":"10.1371/journal.pone.0165214","title":"MATE2 Expression Is Associated with Cancer Cell Response to Metformin","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"Terry Fox Research Institute; Prostate Cancer Canada; Turun Yliopistollinen Keskussairaala; Princess Margaret Cancer Foundation","keywords":"Metformin; Organic cation transport proteins; Intracellular; Cell culture; Cell growth; LNCaP; Growth inhibition; Cancer cell; Biology; Cancer; Pharmacology; Cancer research; Chemistry; Endocrinology; Internal medicine; Medicine; Cell biology; Biochemistry; Transporter; Diabetes mellitus; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195496,0.0001443087,0.0002153346,0.0005075318,0.0002019391,0.0005645657,0.0001676855,0.000393861,0.002877742],"category_scores_gemma":[0.0005644517,0.0001366508,0.0002909415,0.0004693322,0.0001669416,0.0001579346,0.0002219336,0.0004545914,0.0004613598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176306,"about_ca_system_score_gemma":0.00008779453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004096534,"about_ca_topic_score_gemma":0.0005300016,"domain_scores_codex":[0.9998096,0.00002565936,0.00001967019,0.00005219584,0.00005699861,0.0000359942],"domain_scores_gemma":[0.9993448,0.0001338932,0.000237563,0.00006161224,0.0001110725,0.0001111477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001438649,0.0001116325,0.2452535,0.0001256368,0.0001062376,0.0006017588,0.0001160821,0.0002457902,0.7453822,0.0001748041,0.0006493983,0.005794289],"study_design_scores_gemma":[0.00001538929,0.0003250094,0.8487621,0.00001327142,0.00008678057,0.002527036,0.000214877,0.001404319,0.1429675,0.0001058843,0.003560215,0.00001750333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960672,0.0009418066,0.0007015793,0.00007815864,0.00001955687,0.00001189534,0.001081194,0.00004124283,0.001057361],"genre_scores_gemma":[0.9967697,0.0002447718,0.0003815369,0.00004912983,0.00001209322,0.00001998358,0.001400941,0.00001187023,0.001110078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002877742,"threshold_uncertainty_score":0.009626985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987006497027543,"score_gpt":0.2294470880196091,"score_spread":0.2095770230493336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}