{"id":"W2567192998","doi":"10.1074/jbc.m116.752618","title":"Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"hERG; Ubiquitin ligase; Endoplasmic reticulum; Potassium channel; Cell biology; Ubiquitin; Endoplasmic-reticulum-associated protein degradation; Chemistry; Chaperone (clinical); Hsp70; Biochemistry; Unfolded protein response; Biology; Biophysics; Heat shock protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001142776,0.0002446577,0.0001749452,0.0001305355,0.0001352702,0.000180219,0.0001330943,0.0001406996,0.001186353],"category_scores_gemma":[0.0001081721,0.00007639121,0.0001585314,0.00007869599,0.000105091,0.0001111152,0.0001984457,0.0002612486,0.0007085851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267532,"about_ca_system_score_gemma":0.0001565077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004017197,"about_ca_topic_score_gemma":0.0007491115,"domain_scores_codex":[0.9999019,0.00001751293,0.000007527573,0.00002008381,0.00002360503,0.00002939478],"domain_scores_gemma":[0.9999307,0.000005661989,0.00001563658,0.000007225644,0.00001408548,0.00002667345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001805856,0.00004230589,0.000367232,0.00002313531,0.000007861835,0.00006657123,0.000006600678,0.00005837772,0.9978823,0.00005523741,0.0001574411,0.001152394],"study_design_scores_gemma":[0.00002263211,0.0001463886,0.006227774,0.000002932504,0.0000100942,0.0003718242,0.00001253416,0.001636952,0.9896773,0.00002709614,0.001861102,0.000003265481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972018,0.0009048458,0.0009103333,0.00009218448,0.00001848159,0.000008329583,0.0001268606,0.00008153699,0.0006556916],"genre_scores_gemma":[0.9965661,0.0002005174,0.0006762148,0.0000458875,0.000004950729,0.000009242936,0.0003442756,0.00001624322,0.002136535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001186353,"threshold_uncertainty_score":0.003968716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03234883106835167,"score_gpt":0.3035632836605779,"score_spread":0.2712144525922262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}