{"id":"W2567192998","doi":"10.1074/jbc.m116.752618","title":"Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"hERG; Ubiquitin ligase; Endoplasmic reticulum; Potassium channel; Cell biology; Ubiquitin; Endoplasmic-reticulum-associated protein degradation; Chemistry; Chaperone (clinical); Hsp70; Biochemistry; Unfolded protein response; Biology; Biophysics; Heat shock protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008660945,0.0002660862,0.0004442901,0.00005080361,0.00007945232,0.00002116033,0.0004894944,0.0006845343,0.0006225571],"category_scores_gemma":[0.0004987268,0.0001598209,0.0002694749,0.0001050716,0.0002642069,0.00001123779,0.0001492429,0.0003320623,0.00001773876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007584918,"about_ca_system_score_gemma":0.0001484006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005825493,"about_ca_topic_score_gemma":8.221469e-7,"domain_scores_codex":[0.9977647,0.0001813283,0.0008423506,0.0003796621,0.0004094329,0.0004225236],"domain_scores_gemma":[0.9984496,0.00005569512,0.0005040084,0.0003537215,0.0003685774,0.0002684105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002696697,0.0003009494,0.0009073511,0.00004321427,0.0001903002,0.00005020244,0.00001554337,0.000003473265,0.9955552,0.000004883044,0.0002952202,0.002363963],"study_design_scores_gemma":[0.001580888,0.001017518,0.0005024516,0.00009657688,0.00002400486,0.0002547509,0.00002622367,0.000004912093,0.9948645,0.0001830172,0.001225949,0.0002192385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971244,0.0009319079,0.0003456393,0.0006223216,0.00005317826,0.0002119795,0.00004259486,0.00001272125,0.0006552706],"genre_scores_gemma":[0.9960817,0.0003338181,0.0004100279,0.00003718809,0.0003572333,0.00001474555,0.00005113487,0.00002914405,0.002685017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002144725,"threshold_uncertainty_score":0.6816564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03234883106835167,"score_gpt":0.3035632836605779,"score_spread":0.2712144525922262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}