{"id":"W2567225699","doi":"10.1136/annrheumdis-2016-210025","title":"Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases","year":2016,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; University of Saskatchewan","funders":"Canadian Arthritis Network; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Norwegian Institute of Public Health; Medical Research Council; Wake Forest School of Medicine; National Institutes of Health; Doris Duke Charitable Foundation; Arthritis Foundation; Helse Midt-Norge; National Institute of Allergy and Infectious Diseases; Versus Arthritis; Ministry of Education, India; Ministerio de Economía y Competitividad; Great Ormond Street Hospital for Children; University of Manchester; Arthritis Society; Cincinnati Children's Hospital Medical Center; Marcus Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Norges Teknisk-Naturvitenskapelige Universitet; National Institute for Health and Care Research; NHS Blood and Transplant; Bundesministerium für Bildung und Forschung; Fundación Bechara; University of Utah; Wellcome Trust; University College London; Emory University; Canadian Institutes of Health Research; Juvenile Diabetes Research Foundation International; Sparks","keywords":"Polyarthritis; Oligoarthritis; Medicine; Arthritis; PTPN22; Human leukocyte antigen; Immunology; Disease; Single-nucleotide polymorphism; Genotype; Genetics; Antigen; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004294419,0.0001217371,0.0001655913,0.00052962,0.000191994,0.0002495719,0.0001329475,0.000155394,0.001143154],"category_scores_gemma":[0.000810551,0.00007834355,0.0001757204,0.0004444236,0.0001948031,0.00006338483,0.000258206,0.0002236615,0.0001582152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008007838,"about_ca_system_score_gemma":0.0000902241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189159,"about_ca_topic_score_gemma":0.002234177,"domain_scores_codex":[0.9997184,0.00005884836,0.00002197233,0.0001107597,0.0000439519,0.00004605654],"domain_scores_gemma":[0.9991173,0.0003507062,0.0002930324,0.00008510912,0.00004615786,0.0001076732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005332025,0.00004784473,0.7549393,0.00004371453,0.0001481511,0.00029465,0.0002156059,0.0002851176,0.2352384,0.0001018841,0.0001098648,0.00804222],"study_design_scores_gemma":[0.000006826136,0.00006637344,0.9977489,0.000003949459,0.00002682678,0.0002867727,0.00004181264,0.0002609993,0.001365287,0.00004406934,0.0001454246,0.000002610398],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993101,0.00007628305,0.00040351,0.000005357168,8.260665e-7,0.000002240209,0.00008779724,0.000003676471,0.0001101331],"genre_scores_gemma":[0.9994904,0.00002272277,0.0002752539,0.000008298958,0.000001992303,0.000002530583,0.0001428019,0.000001743065,0.00005422558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189159,"threshold_uncertainty_score":0.003824234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03770455386113351,"score_gpt":0.2969360555130579,"score_spread":0.2592315016519243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}