{"id":"W2567257687","doi":"10.1212/wnl.86.16_supplement.p5.105","title":"Autonomic Dysfunction in Familial Amyloid Polyneuropathy Associated with Transthyretin Alanine 60 Variant (P5.105)","year":2016,"lang":"en","type":"article","venue":"Neurology","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital; Western University","funders":"","keywords":"Transthyretin; Amyloid polyneuropathy; Polyneuropathy; Medicine; Autonomic neuropathy; Amyloid (mycology); Internal medicine; Amyloidosis; Alanine; Gastroenterology; Endocrinology; Pathology; Genetics; Biology; Amino acid; Age of onset; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002331112,0.0006591138,0.0002376788,0.0007538932,0.0003712432,0.0002742815,0.0001642241,0.0004220017,0.001442202],"category_scores_gemma":[0.0007036036,0.0001449757,0.0002256537,0.0003240445,0.0002975488,0.0002545029,0.0002403182,0.0001807285,0.0001682884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001466789,"about_ca_system_score_gemma":0.0000824017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332711,"about_ca_topic_score_gemma":0.0008636947,"domain_scores_codex":[0.9998679,0.00002005886,0.00001836364,0.00004172045,0.00002007147,0.00003194849],"domain_scores_gemma":[0.9997873,0.00005808184,0.00006586275,0.000007367184,0.00001580754,0.00006547565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001153418,0.0002197683,0.9312252,0.00005524771,0.00008144768,0.03981316,0.0008578062,0.0001472601,0.01879914,0.00005997248,0.0001619932,0.007425598],"study_design_scores_gemma":[0.00002659486,0.0009037911,0.9580943,0.00001202968,0.00003989354,0.03975727,0.0002912983,0.0002228014,0.0004350434,0.00004273843,0.0001665802,0.000007768845],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997007,0.00008845063,0.00004452267,0.000005488969,0.000002330253,0.000002667381,0.00001632534,0.000002375261,0.0001370225],"genre_scores_gemma":[0.9997923,0.0000360658,0.00003835752,0.00001113577,0.000005614878,0.000002136868,0.00003907207,9.437186e-7,0.0000743885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442202,"threshold_uncertainty_score":0.004824638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004741129157721256,"score_gpt":0.1854697306616622,"score_spread":0.1807286015039409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}