{"id":"W2567285457","doi":"10.1158/1538-7445.am2015-4124","title":"Abstract 4124: Potent anti-tumor and metastatic breast cancer efficacy of bevacizumab with CRLX101, an investigational chemotherapy nanoparticle-drug conjugate that secondarily suppresses HIF-1α","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Bevacizumab; Medicine; Metastatic breast cancer; Cancer research; Metastasis; Breast cancer; Camptothecin; Cancer; Primary tumor; Chemotherapy; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327136,0.0003477431,0.000348348,0.0001769411,0.0001071366,0.0002359452,0.0001785922,0.0003061928,0.001060408],"category_scores_gemma":[0.0001000786,0.0001214299,0.0001590235,0.0001064983,0.0001320076,0.0001345314,0.0001125175,0.0004601052,0.0002436232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003532931,"about_ca_system_score_gemma":0.0002789465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028522,"about_ca_topic_score_gemma":0.001527878,"domain_scores_codex":[0.9998957,0.0000229268,0.000007513877,0.00001993017,0.00003138378,0.00002262299],"domain_scores_gemma":[0.9999512,0.00000781943,0.00001090936,0.000003945683,0.000006829236,0.00001917666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005943083,0.0003757285,0.0001414281,0.00005521756,0.00001339672,0.00008262043,0.00001406525,0.000301853,0.9931071,0.00006264146,0.0002121469,0.005039589],"study_design_scores_gemma":[0.0002334038,0.007921224,0.002218637,0.000005784336,0.00003420124,0.000377287,0.000008410118,0.001802359,0.9849127,0.00001626949,0.002462891,0.000006838421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952213,0.001346216,0.0009383341,0.0001333228,0.00005293297,0.00008599576,0.0002030042,0.00006697164,0.001951921],"genre_scores_gemma":[0.9958646,0.0004820393,0.001223245,0.00004477485,0.00001321675,0.00004081745,0.0003556554,0.00001255387,0.001963073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001060408,"threshold_uncertainty_score":0.00354737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06838471154283565,"score_gpt":0.3295536353781001,"score_spread":0.2611689238352645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}