{"id":"W2567331551","doi":"10.1002/art.40034","title":"Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis","year":2016,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Vasculitis and related conditions","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McMaster University; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Center for Research Resources; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Rare Diseases Clinical Research Network; National Cancer Institute; University of Toronto; National Natural Science Foundation of China","keywords":"Microscopic polyangiitis; PTPN22; Immunology; Granulomatosis with polyangiitis; Haplotype; Human leukocyte antigen; Locus (genetics); Vasculitis; Anti-neutrophil cytoplasmic antibody; Genome-wide association study; Single-nucleotide polymorphism; Biology; Autoantibody; Allele; Population; Genetics; Gene; Disease; Medicine; Genotype; Antibody; Internal medicine; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001030738,0.0008269448,0.0007943942,0.0008993989,0.0002856857,0.0007069585,0.000576623,0.001176717,0.001806298],"category_scores_gemma":[0.00211724,0.000294818,0.001300503,0.001569849,0.0003314603,0.00024771,0.0003344274,0.0006204072,0.0002018065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000133987,"about_ca_system_score_gemma":0.0001950272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293193,"about_ca_topic_score_gemma":0.001004921,"domain_scores_codex":[0.9990705,0.0002316006,0.00008932066,0.0003914849,0.0001304698,0.00008672989],"domain_scores_gemma":[0.9983507,0.0006087667,0.0006368862,0.000162485,0.0001010187,0.0001401077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003432502,0.000133655,0.9616473,0.0002131256,0.00648021,0.0008828926,0.00008729757,0.0006543944,0.01743536,0.0001310078,0.0002991446,0.008603091],"study_design_scores_gemma":[0.0001519279,0.0002580981,0.9937958,0.00002459777,0.002113827,0.000990688,0.00003835986,0.001008683,0.0010954,0.0001534501,0.0003573681,0.00001177357],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954441,0.002953864,0.0006372968,0.0001062042,0.00002560391,0.000007131965,0.0005562769,0.0000182148,0.000251317],"genre_scores_gemma":[0.9990239,0.0002313651,0.0002927916,0.00003777299,0.00003143079,0.000006448487,0.0002669826,0.000006545427,0.0001027542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001806298,"threshold_uncertainty_score":0.006042659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006719969154159472,"score_gpt":0.2144677445510819,"score_spread":0.2077477753969224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}