{"id":"W2567389228","doi":"10.1038/srep39861","title":"CTCF interacts with the lytic HSV-1 genome to promote viral transcription","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Kunming Institute of Zoology, Chinese Academy of Sciences; Institute of Zoology, Chinese Academy of Sciences; National Natural Science Foundation of China; Chinese Academy of Sciences; National Cancer Institute; National Science Foundation","keywords":"CTCF; Lytic cycle; Biology; Chromatin; Gene knockdown; Transcription (linguistics); RNA polymerase II; Genome; Gene; Virus latency; Virology; Genetics; Transcription factor; Virus; Viral replication; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288401,0.0002177104,0.0002796356,0.0003294453,0.0002498402,0.000509825,0.0001751417,0.0002977478,0.002554698],"category_scores_gemma":[0.0003231708,0.0001674213,0.0003021559,0.0002264888,0.0002036715,0.0001945876,0.0004626589,0.0006529292,0.0005934459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006917604,"about_ca_system_score_gemma":0.0003224095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002577233,"about_ca_topic_score_gemma":0.004628503,"domain_scores_codex":[0.9997593,0.00001789545,0.000007413947,0.00004884151,0.00009235068,0.00007422998],"domain_scores_gemma":[0.9998722,0.00002581314,0.00002048053,0.00001263529,0.00002008553,0.00004873535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005249546,0.00001498196,0.0008302368,0.00005387551,0.000008576646,0.00004921813,0.00002565172,0.0000974822,0.9935721,0.0002069123,0.0003097591,0.004778811],"study_design_scores_gemma":[0.00001960507,0.00007441297,0.01155536,0.00001972633,0.00001318344,0.0001877568,0.00003825859,0.002280962,0.9735912,0.0001606474,0.01204913,0.000009761714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615024,0.01220279,0.01691742,0.0003301094,0.0002383691,0.00007495131,0.001144408,0.0006099417,0.006979718],"genre_scores_gemma":[0.9915785,0.000914839,0.003092034,0.0001307338,0.00001691603,0.00002956845,0.0007686523,0.00006742503,0.003401309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002577233,"threshold_uncertainty_score":0.008546293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027334126893882,"score_gpt":0.2890527586162164,"score_spread":0.2687794173472776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}