{"id":"W2567467595","doi":"10.1016/s1525-0016(16)34186-7","title":"577. DNA Ministrings: Linear-Covalently Closed Minivectors for Use in Non-Viral Gene Therapy with Applications Toward Ovarian Cancer","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Plasmid; Insertional mutagenesis; In vitro recombination; Biology; DNA; Transfection; Molecular biology; Bacteriophage; Gene delivery; Gene; Vectors in gene therapy; Escherichia coli; Recombinant DNA; Genetics; Gene expression; Molecular cloning; Viral vector; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003556749,0.0006839015,0.0003310043,0.000516063,0.0002344253,0.0004482964,0.0004708219,0.0005003514,0.004397227],"category_scores_gemma":[0.0002177083,0.0003355163,0.0003120034,0.0004958388,0.0003535131,0.0003711417,0.0003813739,0.0008000428,0.004590522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004189466,"about_ca_system_score_gemma":0.0004864422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003212644,"about_ca_topic_score_gemma":0.0005755825,"domain_scores_codex":[0.9996692,0.00005517275,0.00002826761,0.00005803113,0.0001583645,0.0000310232],"domain_scores_gemma":[0.9998745,0.00001919409,0.00004082647,0.00001476025,0.00002543078,0.00002532373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001109159,0.00004374681,0.0001409934,0.0002210416,0.000008669368,0.00005026725,0.00003350425,0.0001100628,0.9794754,0.001207999,0.001197096,0.01740035],"study_design_scores_gemma":[0.00001763303,0.0002698767,0.0005473942,0.00001955609,0.00001510934,0.0003221633,0.000006924436,0.00052682,0.9627672,0.0001197461,0.03537666,0.00001083145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4623263,0.01829779,0.453416,0.0008197254,0.0007506232,0.002299456,0.008984897,0.007256044,0.045849],"genre_scores_gemma":[0.5935838,0.01493804,0.257714,0.0006979516,0.0001478281,0.00150238,0.02243755,0.001249274,0.1077292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004397227,"threshold_uncertainty_score":0.01471013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03117729556865137,"score_gpt":0.2788771897305189,"score_spread":0.2476998941618676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}