{"id":"W2567553314","doi":"10.1093/nar/gkw1220","title":"Single-cell profiling reveals that eRNA accumulation at enhancer–promoter loops is not required to sustain transcription","year":2016,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Institute for Research in Immunology and Cancer; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Enhancer; Enhancer RNAs; Biology; Transcription (linguistics); Promoter; RNA polymerase II; Chromatin; Transcription factor; Regulation of gene expression; Cell biology; Molecular biology; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009258437,0.0001919346,0.0001722184,0.0001279576,0.0002304865,0.00007922752,0.0003964663,0.000281413,0.0001774609],"category_scores_gemma":[0.0001257457,0.000156776,0.0001039609,0.0001787636,0.00008708239,0.00001625777,0.000296879,0.0001365547,0.0001948742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002914589,"about_ca_system_score_gemma":0.00008226113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001622147,"about_ca_topic_score_gemma":0.00002108092,"domain_scores_codex":[0.9977133,0.0001670012,0.0002916549,0.0006483184,0.000514586,0.0006651793],"domain_scores_gemma":[0.9987344,0.00003165295,0.00007288907,0.0006459768,0.000324671,0.0001904323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002802781,0.0000705053,0.001721187,0.00005598702,0.00001763927,0.000003291138,0.0002627319,0.000007439854,0.9876866,0.00004912629,0.001614428,0.008230731],"study_design_scores_gemma":[0.0007202722,0.0005015538,0.001358485,0.00004685317,0.000006762874,0.000004624614,0.0001229424,0.0002529495,0.985193,0.0003019646,0.01125974,0.0002308337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926161,0.00009617553,0.003361008,0.001636196,0.00009976431,0.0006268975,0.00006277379,0.00002056981,0.001480574],"genre_scores_gemma":[0.9832008,0.0001235187,0.002420414,0.0002225429,0.0002228499,0.00004787552,0.00006944605,0.00006276945,0.01362971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01214914,"threshold_uncertainty_score":0.639314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07175876430745154,"score_gpt":0.3354156144524571,"score_spread":0.2636568501450056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}