{"id":"W2567618958","doi":"10.1016/s1525-0016(16)34108-9","title":"499. Retinal Gene Therapy for Peroxisome Biogenesis Disorders","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Zellweger syndrome; Peroxisomal disorder; Retinal degeneration; Retina; Retinal; Pathology; Genetics; Medicine; Gene; Neuroscience; Peroxisome; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007762896,0.0003872695,0.000206303,0.0004640449,0.0002100863,0.0003072626,0.0002327396,0.0005541397,0.012088],"category_scores_gemma":[0.00005394175,0.0000692565,0.0002640168,0.0001596516,0.0001806019,0.0001386984,0.0002063798,0.0005916283,0.003969509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003088989,"about_ca_system_score_gemma":0.0002163072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008554269,"about_ca_topic_score_gemma":0.001577919,"domain_scores_codex":[0.9999309,0.000006130677,0.000003658316,0.00001481775,0.00003315859,0.0000113551],"domain_scores_gemma":[0.9999788,0.00000282808,0.000005092456,0.000002677544,0.000004233228,0.000006281086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003839431,0.0004238153,0.0005729007,0.0002645709,0.00003397454,0.00111835,0.0000399876,0.0002426527,0.8317794,0.005414424,0.01277584,0.1469502],"study_design_scores_gemma":[0.0003927122,0.003097285,0.01237382,0.0001815042,0.000139649,0.01229271,0.00005846071,0.00183194,0.5374203,0.001663667,0.4305012,0.00004681538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4352584,0.09607975,0.06840582,0.006156891,0.002599039,0.0009290366,0.003900794,0.004413925,0.3822562],"genre_scores_gemma":[0.6941323,0.04145334,0.02938433,0.002677142,0.0004322161,0.0004678938,0.002477914,0.0003105328,0.2286643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.012088,"threshold_uncertainty_score":0.04043841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013452073102781,"score_gpt":0.2664681351784858,"score_spread":0.246333614447458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}