{"id":"W2567618958","doi":"10.1016/s1525-0016(16)34108-9","title":"499. Retinal Gene Therapy for Peroxisome Biogenesis Disorders","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Zellweger syndrome; Peroxisomal disorder; Retinal degeneration; Retina; Retinal; Pathology; Genetics; Medicine; Gene; Neuroscience; Peroxisome; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000326904,0.0003941074,0.0002766556,0.0001036075,0.0001232835,0.00005649748,0.0004387586,0.0003134935,0.00003125252],"category_scores_gemma":[0.00006461803,0.0003571094,0.0002948226,0.0002089819,0.0001280162,0.00000896856,0.00006252154,0.0001056021,0.00002368025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000465892,"about_ca_system_score_gemma":0.0002011264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002602869,"about_ca_topic_score_gemma":0.000005248689,"domain_scores_codex":[0.9980556,0.0001578943,0.0002809417,0.0006830231,0.0002873464,0.0005351818],"domain_scores_gemma":[0.9987681,0.00001156185,0.0001148747,0.000639683,0.000202755,0.0002630353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001098568,0.0002073373,0.002007458,0.000004137069,0.0002249588,0.000002479499,0.00009077645,0.00006262717,0.9783626,0.00004364145,0.001505727,0.01638971],"study_design_scores_gemma":[0.002904276,0.001228823,0.0001232406,0.000003592022,0.000007582991,0.00001006189,0.00005599423,0.00002548183,0.8173802,0.0003213222,0.177537,0.0004023125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758387,0.01057244,0.01137736,0.0006522762,0.0003456786,0.0008353086,0.00005484734,0.00006502314,0.0002583679],"genre_scores_gemma":[0.9899877,0.003376053,0.003437368,0.001623398,0.0003579129,0.0003783417,0.0003944678,0.0001501287,0.0002946391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1760313,"threshold_uncertainty_score":0.9998881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013452073102781,"score_gpt":0.2664681351784858,"score_spread":0.246333614447458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}