{"id":"W2567625255","doi":"10.1042/cs20160251","title":"Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling","year":2016,"lang":"en","type":"article","venue":"Clinical Science","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North; Laurentian University; Thunder Bay Regional Research Institute; Lakehead University","funders":"","keywords":"Fructose; Carbohydrate-responsive element-binding protein; Internal medicine; Endocrinology; Aldolase B; Vascular smooth muscle; Gene knockdown; Chemistry; Fructolysis; Glycolysis; Aldolase A; Biology; Fructose-bisphosphate aldolase; Apoptosis; Biochemistry; Metabolism; Medicine; Transcription factor; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001607492,0.00008680487,0.0002857081,0.00008087505,0.00009807966,0.00001609392,0.00006874052,0.00006757728,0.000005469562],"category_scores_gemma":[0.005124683,0.0000529173,0.00008080109,0.0001719292,0.0007136891,0.0001517097,0.00005062821,0.00005239917,0.000003570772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001055182,"about_ca_system_score_gemma":0.0001639928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003591434,"about_ca_topic_score_gemma":0.000001239268,"domain_scores_codex":[0.9987508,0.00004708136,0.000289817,0.0004079044,0.000304433,0.0001999537],"domain_scores_gemma":[0.9980513,0.001084865,0.0001124371,0.0002810244,0.0001426344,0.0003277546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.007431283,0.001418334,0.1691358,0.001609548,0.0001091569,0.00003164404,0.0007188624,0.00005211299,0.3179049,0.01877058,0.002263069,0.4805547],"study_design_scores_gemma":[0.006019576,0.0009677446,0.9606996,0.0007271785,0.0001719169,0.000002587628,0.00004420943,0.004018694,0.01876304,0.006853952,0.001578224,0.0001533158],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957295,0.000459899,0.002390443,0.0005516533,0.0003374429,0.000411723,0.000004978693,0.00001605815,0.00009827602],"genre_scores_gemma":[0.9974632,0.000278872,0.001502653,0.0002985817,0.0001765375,0.000007499626,7.443409e-7,0.000007007492,0.000264862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7915638,"threshold_uncertainty_score":0.6135094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04565422137335665,"score_gpt":0.3722750876083717,"score_spread":0.3266208662350151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}