{"id":"W2567630940","doi":"10.1016/s1525-0016(16)32990-2","title":"181. Optimization of In Vivo Delivery of Baculovirus Gene Therapy Vectors for the Treatment of Alpha-1 Antitrypsin Deficiency","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Genetic enhancement; Gene delivery; Neutrophil elastase; Alpha 1-antitrypsin deficiency; Immunology; Biology; Lung; In vivo; Vector (molecular biology); Elastase; Reporter gene; Medicine; Gene; Inflammation; Gene expression; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003939604,0.0005047553,0.0004317,0.0003602275,0.0002498871,0.0005737063,0.0003184191,0.0005850275,0.001193651],"category_scores_gemma":[0.0002482722,0.0002079077,0.0004347733,0.0003088359,0.000190577,0.0003151718,0.000176342,0.0006119751,0.0006468262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004574439,"about_ca_system_score_gemma":0.0003011815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009210825,"about_ca_topic_score_gemma":0.0008648768,"domain_scores_codex":[0.9996146,0.00007588314,0.00005331536,0.00007773031,0.0001270667,0.00005148441],"domain_scores_gemma":[0.9998844,0.00002413948,0.0000393758,0.000009343381,0.00002511838,0.00001765183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007973197,0.0000846015,0.00008993741,0.00007167468,0.000006413237,0.0000441952,0.00001947303,0.0003151714,0.9959544,0.0002158655,0.00008713633,0.003031388],"study_design_scores_gemma":[0.00002286651,0.0006947918,0.0005607755,0.0000102709,0.00002428214,0.0001456138,0.00001578028,0.001299898,0.9909862,0.000046417,0.006184441,0.000008616534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9391893,0.008207142,0.04344493,0.0003203569,0.0002947503,0.000728319,0.001326079,0.0002621814,0.006226854],"genre_scores_gemma":[0.9151663,0.007558849,0.06001414,0.0001978235,0.00004521082,0.0007233793,0.00341941,0.0001641626,0.01271081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193651,"threshold_uncertainty_score":0.003993154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141703296223729,"score_gpt":0.2636977902267106,"score_spread":0.2495274606043378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}