{"id":"W2567630940","doi":"10.1016/s1525-0016(16)32990-2","title":"181. Optimization of In Vivo Delivery of Baculovirus Gene Therapy Vectors for the Treatment of Alpha-1 Antitrypsin Deficiency","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Genetic enhancement; Gene delivery; Neutrophil elastase; Alpha 1-antitrypsin deficiency; Immunology; Biology; Lung; In vivo; Vector (molecular biology); Elastase; Reporter gene; Medicine; Gene; Inflammation; Gene expression; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007702821,0.0001378761,0.000186797,0.00005698324,0.00003203336,0.000003813307,0.000144384,0.00008694258,0.00004637977],"category_scores_gemma":[0.00001109005,0.00007822979,0.0002203505,0.0001080741,0.00009971829,0.000004000236,0.00001303098,0.00001184744,2.583922e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001332229,"about_ca_system_score_gemma":0.00005952642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009457141,"about_ca_topic_score_gemma":0.000007127167,"domain_scores_codex":[0.9992009,0.00006552939,0.0002732889,0.0002078545,0.0001105373,0.0001419247],"domain_scores_gemma":[0.9993033,0.0000337214,0.0001728434,0.0003426794,0.0001213228,0.00002615009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006349089,0.0005074341,0.002299027,0.000007864222,0.0000914063,6.020683e-7,0.00005912108,0.0042091,0.9790983,0.00002569321,0.00008178332,0.01298481],"study_design_scores_gemma":[0.00240132,0.002133886,0.0009437763,0.00001727041,0.00001153244,8.984948e-7,0.00001490979,0.0001615482,0.9920634,0.00005122558,0.002103651,0.00009655896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607599,0.01551764,0.02300591,0.0000370423,0.00009558602,0.00045895,0.00007734088,0.000003543411,0.00004412812],"genre_scores_gemma":[0.9766893,0.02248572,0.0006054635,0.00005680913,0.00002812296,0.00006442954,0.00001244829,0.00002051934,0.00003718597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02240044,"threshold_uncertainty_score":0.3190118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141703296223729,"score_gpt":0.2636977902267106,"score_spread":0.2495274606043378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}