{"id":"W2567717834","doi":"10.1158/1538-7445.am2015-1000","title":"Abstract 1000: Tyrosine kinase receptor EGFR regulates the switch between cell survival and cell death induced by autophagy under hypoxia in cancer cells","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Autophagy; Programmed cell death; Hypoxia (environmental); Cell biology; Cancer cell; Cancer research; Tyrosine kinase; Receptor tyrosine kinase; Biology; Cell; Kinase; Chemistry; Apoptosis; Signal transduction; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004344012,0.0001989206,0.0002199085,0.0001332878,0.0002016051,0.0002211048,0.0001319278,0.0002599653,0.003741558],"category_scores_gemma":[0.00004371782,0.0000888533,0.0001791723,0.0001930103,0.00009003941,0.0001792755,0.0001445373,0.0003868908,0.0008853399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817714,"about_ca_system_score_gemma":0.0001460999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006638261,"about_ca_topic_score_gemma":0.0005833132,"domain_scores_codex":[0.9999299,0.000006357628,0.000005860067,0.00001433346,0.00002031409,0.00002323894],"domain_scores_gemma":[0.9999731,0.000003211809,0.000007242611,0.000001707439,0.000005359285,0.000009403174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002469473,0.00003858785,0.0004483218,0.00008344727,0.000006392065,0.0001027052,0.00001287843,0.00004135792,0.9964129,0.00008801366,0.0003322006,0.002186235],"study_design_scores_gemma":[0.00005278374,0.0003308454,0.04042224,0.00001802994,0.00003231945,0.0009559423,0.00006127571,0.001361327,0.9489493,0.0001120636,0.007694108,0.000009766877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855034,0.006690943,0.001313259,0.0003618744,0.0001194805,0.00002945919,0.001150674,0.0001440711,0.004686836],"genre_scores_gemma":[0.9875686,0.001894151,0.0008172564,0.0001435464,0.00003128682,0.00005642175,0.001343846,0.00001969648,0.008125236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003741558,"threshold_uncertainty_score":0.0125168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07168070882385823,"score_gpt":0.3524546105303704,"score_spread":0.2807739017065122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}