{"id":"W2567813614","doi":"10.1212/wnl.86.16_supplement.s49.002","title":"Effect of Ocrelizumab on MRI Inflammatory and Neurodegenerative Markers of Disease in Patients with Relapsing Multiple Sclerosis: Analysis of the Phase III, Double-Blind, Double-Dummy, Interferon Beta-1a-Controlled OPERA I and OPERA II Studies (S49.002)","year":2016,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Montreal Neurological Institute and Hospital","funders":"","keywords":"Ocrelizumab; Multiple sclerosis; Medicine; Interferon beta-1a; Interferon beta; Double blind; BETA (programming language); Disease; Relapsing remitting; Oncology; Internal medicine; Pathology; Immunology; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003113084,0.001495474,0.002722265,0.0003512551,0.0003035925,0.0009903546,0.000589572,0.001297468,0.001682405],"category_scores_gemma":[0.002084785,0.0005727264,0.002285735,0.0003267771,0.0009857448,0.0008224691,0.0003228927,0.002523839,0.0003291267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007078325,"about_ca_system_score_gemma":0.0009432322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000528498,"about_ca_topic_score_gemma":0.001005494,"domain_scores_codex":[0.9990106,0.0005767546,0.00007677655,0.0001457795,0.00007340014,0.0001167612],"domain_scores_gemma":[0.9980335,0.0006050567,0.0005520962,0.0001495116,0.00009787295,0.0005620666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9582523,0.006502095,0.0025919,0.0004300293,0.001064425,0.00003963178,0.00005654793,0.0003452979,0.006180569,0.00004684578,0.0003505732,0.02413972],"study_design_scores_gemma":[0.7011435,0.2817951,0.01267145,0.00004762305,0.001093316,0.00009997249,0.00003139639,0.0005941119,0.001738033,0.00009196618,0.0006619989,0.00003151612],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941748,0.003952393,0.0002045208,0.0002209094,0.0001113838,0.0004368473,0.0003265439,0.00003074908,0.0005418707],"genre_scores_gemma":[0.9961419,0.001350726,0.000537638,0.000347669,0.0001992142,0.0004178232,0.0005382534,0.000009760061,0.0004571148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003113084,"threshold_uncertainty_score":0.01646382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0347704689077195,"score_gpt":0.3081642384510105,"score_spread":0.273393769543291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}