{"id":"W2567819266","doi":"10.1097/cad.0000000000000469","title":"Effect of dihydroartemisinin on UHRF1 gene expression in human prostate cancer PC-3 cells","year":2017,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artron Bioresearch (Canada)","funders":"Chongqing Municipal Education Commission","keywords":"DNMT1; Downregulation and upregulation; DNA methylation; Apoptosis; Cancer research; Cell cycle; Prostate cancer; Biology; Cancer cell; DNA methyltransferase; Methylation; Cancer; Molecular biology; Chemistry; Gene expression; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003243799,0.0001772144,0.000240794,0.00004636624,0.0001516817,0.00003119215,0.0002556521,0.0001386802,0.00002443742],"category_scores_gemma":[0.0000219404,0.0001527651,0.00007936968,0.00003479759,0.00009031792,0.000007239877,0.0001075765,0.00009625882,0.000003360618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002110181,"about_ca_system_score_gemma":0.00004149284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003906569,"about_ca_topic_score_gemma":0.00007440524,"domain_scores_codex":[0.9988887,0.00009284701,0.0002403957,0.0003827933,0.000164284,0.0002310354],"domain_scores_gemma":[0.9990273,0.0000156491,0.000271022,0.0005868278,0.00004470522,0.0000545675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025374,0.00004490872,0.03889016,0.00005957309,0.00001537502,0.000001279242,0.0001263696,0.0005638428,0.9518335,0.000002164305,0.0001640214,0.008196256],"study_design_scores_gemma":[0.001150099,0.0003596714,0.01006135,0.000139689,0.00001397191,6.036593e-8,0.000007361474,0.00003495184,0.9860536,0.00001859685,0.001988815,0.0001717933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968208,0.001677514,0.00001286306,0.0000727907,0.000250784,0.000285565,0.00005038088,0.000005084267,0.0008242276],"genre_scores_gemma":[0.9957761,0.002988084,0.00004363019,0.00003097808,0.0002002333,0.00007416368,0.00003918931,0.00002802512,0.0008195698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03422013,"threshold_uncertainty_score":0.6229581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009098106776582633,"score_gpt":0.3157188842599165,"score_spread":0.3066207774833338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}