{"id":"W2567980438","doi":"10.1016/j.meegid.2017.01.006","title":"Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection","year":2017,"lang":"en","type":"article","venue":"Infection Genetics and Evolution","topic":"Hepatitis C virus research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute on Drug Abuse; National Institute of Allergy and Infectious Diseases; Rijksinstituut voor Volksgezondheid en Milieu; National Health and Medical Research Council; National Institutes of Health; Canadian Institutes of Health Research; University of New South Wales","keywords":"Epitope; Virology; Antibody; Biology; Glycoprotein; Neutralization; Neutralizing antibody; Immunology; Conserved sequence; Virus; Peptide sequence; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002873065,0.0001540841,0.000204978,0.0002063912,0.0002184734,0.0004172957,0.0002101428,0.0003399116,0.001032321],"category_scores_gemma":[0.0005744192,0.0001316615,0.0001515498,0.0001955201,0.0003786843,0.0002949349,0.0003330602,0.0004997911,0.000180387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312706,"about_ca_system_score_gemma":0.0001648113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006792691,"about_ca_topic_score_gemma":0.0009830316,"domain_scores_codex":[0.9998828,0.00003310866,0.000008533136,0.0000170467,0.00002230206,0.00003616875],"domain_scores_gemma":[0.9997372,0.00008516241,0.00006431382,0.00002791392,0.00002722652,0.0000581917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001015095,0.000122646,0.05349434,0.00004554449,0.0000477877,0.0007663717,0.0002273854,0.002090566,0.9320933,0.001401702,0.0001212508,0.008573933],"study_design_scores_gemma":[0.0001995435,0.002377497,0.5791102,0.00005834506,0.0001477173,0.01225942,0.001593442,0.03432642,0.3615064,0.004650874,0.003660017,0.0001099969],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995046,0.00004780952,0.0002453755,0.00001027363,8.408911e-7,0.000001305489,0.00001081288,0.000002811031,0.0001762721],"genre_scores_gemma":[0.9997059,0.00002197369,0.0001362215,0.00001732841,0.00000145854,0.000001480723,0.00002498904,0.000003622765,0.00008695224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001032321,"threshold_uncertainty_score":0.003453434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03254637797392847,"score_gpt":0.3548239131363744,"score_spread":0.3222775351624459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}