{"id":"W2568014093","doi":"10.1101/092114","title":"Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in <i>Drosophila</i>","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Cell biology; RNA polymerase III; Repressor; MAPK/ERK pathway; Biology; Protein biosynthesis; Cell growth; Kinase; Effector; RNA polymerase II; Transcription (linguistics); Transcription factor; RNA; RNA polymerase; Molecular biology; Biochemistry; Gene expression; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007378177,0.000288632,0.0001542783,0.0001968047,0.000163227,0.0002963004,0.0001914536,0.0001906073,0.00134198],"category_scores_gemma":[0.00006766983,0.0001846229,0.0002171983,0.00006940903,0.0001532312,0.0001329835,0.0002268947,0.0004068424,0.000721612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004996205,"about_ca_system_score_gemma":0.0001324281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001798935,"about_ca_topic_score_gemma":0.00403571,"domain_scores_codex":[0.9999357,0.000006989851,0.000005815551,0.00001717868,0.00002091518,0.00001340426],"domain_scores_gemma":[0.9999362,0.00000939684,0.00001884921,0.000007502839,0.000007450823,0.0000204945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002563637,0.000002275921,0.0001253831,0.000009488495,0.000001476314,0.00002073931,0.000004088832,0.00002922515,0.9994568,0.00005779443,0.00002456954,0.000242573],"study_design_scores_gemma":[0.00001141724,0.00004397431,0.008415795,0.000005320285,0.000005690907,0.0001354541,0.00001649689,0.00131327,0.9873192,0.00005839093,0.002670999,0.000004022041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925101,0.0009970538,0.002013699,0.0001126211,0.00002051522,0.00001022807,0.000637276,0.0001087694,0.003589778],"genre_scores_gemma":[0.9910643,0.0003612424,0.001541135,0.0000484621,0.000006714351,0.000009273813,0.0007268341,0.00007571726,0.006166308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798935,"threshold_uncertainty_score":0.004489362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007371391240663238,"score_gpt":0.2015503135998713,"score_spread":0.1941789223592081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}