{"id":"W2568220481","doi":"10.1038/gene.2016.44","title":"Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells","year":2017,"lang":"en","type":"article","venue":"Genes and Immunity","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia; Child and Family Research Institute","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; Juvenile Diabetes Research Foundation United States of America","keywords":"Biology; FOXP3; Genotyping; Immunology; Treg cell; Genetics; Genotype; Gene; T cell; Immune system; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003422375,0.000806376,0.0004493158,0.001127504,0.0005547664,0.001031529,0.0004420189,0.001155414,0.004991092],"category_scores_gemma":[0.0009233319,0.0002602373,0.0003949461,0.0005677335,0.0003195525,0.0002607706,0.0002815255,0.0006612111,0.0009765094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001886094,"about_ca_system_score_gemma":0.0001473615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001243636,"about_ca_topic_score_gemma":0.001171597,"domain_scores_codex":[0.9996727,0.00004805198,0.00003213879,0.0001011331,0.00006344089,0.00008264522],"domain_scores_gemma":[0.9994874,0.0001538854,0.0001461865,0.00004431054,0.00006253378,0.000105685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003582201,0.000427074,0.8236655,0.0001421567,0.0001458161,0.00659728,0.0004642707,0.0002588045,0.1373899,0.0003080342,0.001604246,0.02541478],"study_design_scores_gemma":[0.0000628963,0.0007221314,0.9661266,0.00006222488,0.0001702733,0.01571923,0.0004611627,0.0009011409,0.01259637,0.0005812453,0.002564581,0.00003211485],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963714,0.0004548735,0.000778751,0.0001294566,0.00004064853,0.000017353,0.000659826,0.0000603973,0.001487275],"genre_scores_gemma":[0.9981003,0.00008872538,0.0005071237,0.0001031749,0.00003502345,0.00001608698,0.0003314159,0.00002185567,0.0007962167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004991092,"threshold_uncertainty_score":0.01669681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009130473211886906,"score_gpt":0.2369022020246419,"score_spread":0.227771728812755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}