{"id":"W2568226435","doi":"10.1128/iai.00905-16","title":"MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate-Induced Colitis","year":2017,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Cathelicidin; Mucin; Entamoeba histolytica; Mucin 2; Biology; Goblet cell; Mucus; Antimicrobial peptides; Colitis; Microbiology; Biochemistry; Immunology; Antimicrobial; Gene expression; Epithelium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006205608,0.0001328862,0.0002523499,0.0001137619,0.0007496537,0.00005596308,0.00006648649,0.00007527271,0.00001282628],"category_scores_gemma":[0.001013676,0.000085827,0.00004589622,0.00009972477,0.0001620815,0.00007984386,0.0001329793,0.0001885086,0.000005160271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001006263,"about_ca_system_score_gemma":0.00006272065,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01779052,"about_ca_topic_score_gemma":0.004822937,"domain_scores_codex":[0.9991153,0.0002556612,0.0002092655,0.0001633138,0.00007813182,0.0001782928],"domain_scores_gemma":[0.9990373,0.0002173237,0.00009974591,0.0004517959,0.00009116602,0.0001026366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003966463,0.0005718746,0.6410604,0.00008548959,0.0001946876,0.00001933371,0.004330817,0.000002939048,0.3341511,0.000193395,0.0003349466,0.0150886],"study_design_scores_gemma":[0.001395831,0.0002726359,0.9162522,0.000139968,0.00008859983,0.0001197486,0.0001380258,0.00001763306,0.07967927,0.00001707141,0.001796001,0.00008300513],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949013,0.00002151877,0.00001776734,0.003764387,0.0001667377,0.0006492368,0.00004577523,0.0000135133,0.0004197802],"genre_scores_gemma":[0.9991446,0.00009609008,0.00001832254,0.0002729798,0.00002301182,0.0000401109,0.000001444127,0.00001029117,0.0003932026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2751919,"threshold_uncertainty_score":0.9887501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797440403691857,"score_gpt":0.2782741439714305,"score_spread":0.2602997399345119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}