{"id":"W2568539345","doi":"10.1016/j.neurobiolaging.2017.01.003","title":"Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2","year":2017,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; University of California, Irvine; University of California, Davis; GE Healthcare; Genentech; IXICO; H. Lundbeck A/S; Fujirebio Europe; North Bristol NHS Trust; Canadian Institutes of Health Research; Stichting MS Research; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Rush University; U.S. Department of Defense; BRACE; University of Alabama at Birmingham; National Center for Advancing Translational Sciences; Novartis Pharmaceuticals Corporation; Takeda Pharmaceutical Company; Roche; University of Pittsburgh; Higher Education Funding Council for England; University of Arizona; McDonnell Center for Systems Neuroscience; University of California, San Diego; Johns Hopkins University; University of California, Los Angeles; Pfizer; University of Washington; Medical Research Council; Servier; Boston University; Meso Scale Diagnostics; Emory University; U.S. Department of Veterans Affairs; University of Pennsylvania; Columbia University; Massachusetts General Hospital; Translational Genomics Research Institute; Indiana University; Vanderbilt University; Wellcome Trust; University of Southern California; Duke University; AbbVie; National Institutes of Health; Alzheimer's Drug Discovery Foundation; BioClinica; Newcastle University; Icahn School of Medicine at Mount Sinai; Northwestern University; Biogen; University of Miami; Alzheimer's Research Trust; Eli Lilly and Company; Bristol-Myers Squibb; Wellcome; Alzheimer's Association; University of Kentucky; New York University; Oregon Health and Science University; University of Michigan; University of California, San Francisco; Mayo Clinic; Howard Hughes Medical Institute","keywords":"Hippocampal sclerosis; Neuropathology; Haplotype; Genetic association; Genome-wide association study; Biology; Gene; Genetics; Single-nucleotide polymorphism; Medicine; Disease; Allele; Pathology; Neuroscience; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003560659,0.0003557875,0.0004339048,0.001019118,0.0004436329,0.000375664,0.0004355795,0.0004391217,0.001644864],"category_scores_gemma":[0.0009166429,0.0001757161,0.0004823561,0.001201125,0.0003209852,0.0001301541,0.000377985,0.0005111117,0.0002103258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002337468,"about_ca_system_score_gemma":0.0002190843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004790722,"about_ca_topic_score_gemma":0.006469979,"domain_scores_codex":[0.9996235,0.0001003402,0.00003669736,0.0001512278,0.00005026532,0.0000378615],"domain_scores_gemma":[0.9994647,0.0001597336,0.0001723192,0.00005929237,0.00004987331,0.00009410633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005208889,0.0002727349,0.9069858,0.00007249416,0.001554778,0.002270901,0.0003047025,0.0004524823,0.07436626,0.0002597686,0.0004893737,0.007761911],"study_design_scores_gemma":[0.0001151888,0.0002453388,0.9926689,0.000007558702,0.0004983798,0.001944498,0.0001591395,0.001105935,0.002588518,0.0001197995,0.0005353762,0.0000113886],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994025,0.0001271631,0.0001483515,0.00002524828,0.000006254902,0.000002588741,0.0001855913,0.000004975285,0.00009718443],"genre_scores_gemma":[0.9991202,0.00005430184,0.0002853969,0.00002017969,0.000005347514,0.000004623189,0.0002348728,0.000004962612,0.000270106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004790722,"threshold_uncertainty_score":0.009525657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05411631587978322,"score_gpt":0.3284901331932314,"score_spread":0.2743738173134482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}