{"id":"W2569110440","doi":"10.1172/jci91081","title":"Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; Daiichi Sankyo Europe; National Institute on Aging; University of California, San Diego; National Cancer Institute; Yale University; National Institutes of Health; University of California, Los Angeles; Kansai Medical University","keywords":"NUMB; Cell biology; Downregulation and upregulation; Endosome; Notch signaling pathway; YAP1; Biology; Signal transduction; Signal transducing adaptor protein; Cell cycle; Cell; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001616136,0.0001080477,0.000223031,0.0000185969,0.0002527251,0.00009906502,0.0001788634,0.0002030113,0.000001798527],"category_scores_gemma":[0.002198615,0.00009205899,0.0001217747,0.00001664729,0.0001599072,0.00002961178,0.00003537562,0.0001881116,0.000001275396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007007586,"about_ca_system_score_gemma":0.000169739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001193156,"about_ca_topic_score_gemma":0.00000421887,"domain_scores_codex":[0.9986887,0.0001040326,0.0007153797,0.0001975878,0.0001568252,0.0001375016],"domain_scores_gemma":[0.9980879,0.00005218958,0.001221608,0.0001813532,0.0002675957,0.0001893422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001546898,0.00007110134,0.0125375,0.00003871135,0.00003081154,0.00000117613,0.00004298036,0.00001616907,0.9813079,0.00002128849,0.001847445,0.003930212],"study_design_scores_gemma":[0.002352547,0.001772442,0.004653336,0.0001226483,0.00006986526,0.00001309667,0.00004907023,0.002035167,0.9708799,0.001939266,0.01587955,0.0002331159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915656,0.0002094034,0.006767383,0.0008853388,0.0002387716,0.0002349407,0.00001871376,0.000004348368,0.00007553912],"genre_scores_gemma":[0.9797476,0.00007313257,0.01869529,0.0001515498,0.0009401756,0.000005853579,0.00005206641,0.00001745776,0.0003168553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0140321,"threshold_uncertainty_score":0.3754056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591363812443597,"score_gpt":0.3351261989184913,"score_spread":0.2992125607940553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}