{"id":"W2569110440","doi":"10.1172/jci91081","title":"Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; Daiichi Sankyo Europe; National Institute on Aging; University of California, San Diego; National Cancer Institute; Yale University; National Institutes of Health; University of California, Los Angeles; Kansai Medical University","keywords":"NUMB; Cell biology; Downregulation and upregulation; Endosome; Notch signaling pathway; YAP1; Biology; Signal transduction; Signal transducing adaptor protein; Cell cycle; Cell; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107115,0.0002678904,0.0001230921,0.0002029856,0.0002069542,0.0003331971,0.0001119172,0.0001549454,0.001373599],"category_scores_gemma":[0.00009204812,0.0001243917,0.0001289261,0.00008964377,0.0002046275,0.0002234089,0.0004167405,0.0003448011,0.0004023178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003381988,"about_ca_system_score_gemma":0.0002396393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003275031,"about_ca_topic_score_gemma":0.0008536063,"domain_scores_codex":[0.999922,0.00001177073,0.000006870163,0.00001394076,0.00002324364,0.00002207916],"domain_scores_gemma":[0.999944,0.000004098643,0.00002214649,0.000004124668,0.000005209287,0.0000203595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005150569,0.000008111451,0.0004343663,0.00001878115,0.000003589121,0.00005531089,0.000009460584,0.00004761513,0.9981641,0.0002150777,0.00002991977,0.0009621869],"study_design_scores_gemma":[0.00002900958,0.0001128299,0.0153863,0.00001174925,0.0000146446,0.0005742739,0.00007108186,0.002452108,0.9764451,0.0002232167,0.004675182,0.00000450333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937626,0.001449167,0.002854544,0.0001327827,0.00001435306,0.000009127885,0.0001136086,0.00005652602,0.001607323],"genre_scores_gemma":[0.9955875,0.0006630533,0.001228186,0.00002927096,0.000004115083,0.00001332394,0.0001315113,0.00001190738,0.002331001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001373599,"threshold_uncertainty_score":0.004595101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591363812443597,"score_gpt":0.3351261989184913,"score_spread":0.2992125607940553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}