{"id":"W2569347110","doi":"10.1371/journal.pone.0169338","title":"Differential HDAC1 and 2 Recruitment by Members of the MIER Family","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"HDAC1; Histone deacetylase; Histone deacetylase 2; HEK 293 cells; HDAC4; HDAC11; Cytoplasm; Immunoprecipitation; Cell culture; Biology; HDAC10; Cell biology; Histone deacetylase 5; Chemistry; Molecular biology; Genetics; Gene; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000168819,0.000258993,0.0002967969,0.0002269408,0.0001999277,0.0003767848,0.0001707223,0.0002460529,0.001833215],"category_scores_gemma":[0.0001624634,0.000161931,0.0003806324,0.0001821763,0.0001330549,0.0002585213,0.0002548606,0.0004274179,0.0006953832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002742221,"about_ca_system_score_gemma":0.000113085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004242187,"about_ca_topic_score_gemma":0.0008557559,"domain_scores_codex":[0.9997905,0.00002249347,0.00001713391,0.00005987068,0.00004704011,0.00006290726],"domain_scores_gemma":[0.9999285,0.00001433935,0.00001340504,0.00001326603,0.00001113644,0.00001946255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001045343,0.000007066216,0.000624706,0.00003032085,0.000005687381,0.00004603351,0.00002065696,0.00001487522,0.9980795,0.00005383834,0.000046044,0.0009666242],"study_design_scores_gemma":[0.00001341237,0.0001021246,0.04004835,0.000005665513,0.00002013824,0.0006828642,0.00006269563,0.0005464378,0.951946,0.00004601838,0.006519837,0.000006589249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881483,0.004507592,0.003102178,0.00009769441,0.00003633107,0.00002435698,0.001009595,0.00007446871,0.00299958],"genre_scores_gemma":[0.9856248,0.001610185,0.003804697,0.0001247904,0.00002294836,0.00005445873,0.003061232,0.00004163594,0.00565524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001833215,"threshold_uncertainty_score":0.006132662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07174795574654723,"score_gpt":0.2905956139577784,"score_spread":0.2188476582112312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}