{"id":"W2569423324","doi":"10.1139/cjpp-2016-0567","title":"mTORC1 inhibitors rapamycin and metformin affect cardiovascular markers differentially in ZDF rats","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Dialysis Clinics","keywords":"Metformin; Internal medicine; Endocrinology; Medicine; mTORC1; Type 2 diabetes; Diabetes mellitus; Hyperinsulinemia; Urinary system; Insulin resistance; Pharmacology; PI3K/AKT/mTOR pathway; Chemistry; Signal transduction","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002515278,0.000780594,0.0008974432,0.001692954,0.0004239527,0.0003866634,0.0003676339,0.0006844762,0.001767064],"category_scores_gemma":[0.0002065272,0.0004245459,0.0006300453,0.0004749894,0.0007170137,0.000590827,0.0003017008,0.001633747,0.0003001138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007131042,"about_ca_system_score_gemma":0.0005625139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002080512,"about_ca_topic_score_gemma":0.003773853,"domain_scores_codex":[0.999685,0.00003326626,0.00002996436,0.00008080561,0.00006128786,0.0001097524],"domain_scores_gemma":[0.9996169,0.00002936215,0.0001252679,0.00003681293,0.00002929837,0.0001623663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009814105,0.001814765,0.002743236,0.00007748358,0.00007652283,0.000266987,0.00008650961,0.0002110956,0.9764365,0.0002823513,0.000245265,0.007945192],"study_design_scores_gemma":[0.001222249,0.01718893,0.06671656,0.000037886,0.0003900806,0.000675899,0.000556796,0.002301049,0.906494,0.0005043074,0.003809106,0.0001031523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975569,0.0006125188,0.000683472,0.0001532824,0.00005123672,0.00002277292,0.0004302583,0.00007060661,0.0004188615],"genre_scores_gemma":[0.9914038,0.001217296,0.002221602,0.0002027935,0.00003216606,0.0001254809,0.0007247528,0.00004448935,0.004027675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002080512,"threshold_uncertainty_score":0.00591141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009397035584173133,"score_gpt":0.2511338289304447,"score_spread":0.2417367933462716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}