{"id":"W2569801585","doi":"10.17863/cam.946","title":"Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.","year":2016,"lang":"en","type":"article","venue":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancer Research UK; National Institutes of Health; Ovarian Cancer Research Fund; Roswell Park Cancer Institute; Breast Cancer Research Foundation","keywords":"Prostate cancer; Biology; Genome-wide association study; Breast cancer; Ovarian cancer; Meta-analysis; Genetics; Cancer; Locus (genetics); Genetic association; Quantitative trait locus; Gene; Oncology; Single-nucleotide polymorphism; Internal medicine; Genotype; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008021645,0.002157861,0.003435546,0.003238736,0.0007220632,0.002423941,0.001682637,0.001248093,0.003640953],"category_scores_gemma":[0.01039721,0.0006789924,0.0130441,0.005663519,0.0006241249,0.0007316798,0.001821156,0.001487244,0.0003355962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006552331,"about_ca_system_score_gemma":0.0008152443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003985269,"about_ca_topic_score_gemma":0.006279256,"domain_scores_codex":[0.9953653,0.001674498,0.0005632726,0.001539358,0.0005149509,0.0003426134],"domain_scores_gemma":[0.9920884,0.004420784,0.001455862,0.001382485,0.0003700314,0.0002823723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00447074,0.0000521338,0.5725343,0.003942056,0.3890911,0.0006712342,0.0001297038,0.001796457,0.005461297,0.0005254573,0.00150365,0.01982188],"study_design_scores_gemma":[0.0005575987,0.0005121759,0.5968949,0.0007910306,0.3870509,0.001680376,0.0002173241,0.002624819,0.00277175,0.002003816,0.004833601,0.00006179272],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5958837,0.3660038,0.02100814,0.002864422,0.0008013762,0.0001422935,0.01009643,0.0008718644,0.002328097],"genre_scores_gemma":[0.9807811,0.01332053,0.002699167,0.0003442272,0.0002080751,0.00007123645,0.002253745,0.00007271993,0.0002491583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008021645,"threshold_uncertainty_score":0.04242301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09718277180948974,"score_gpt":0.3487056540105171,"score_spread":0.2515228822010274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}