{"id":"W2569973043","doi":"10.1182/blood.v106.11.1949.1949","title":"Human Factor VIIai(K62E) Is a More Effective Inhibitor of Coagulation Than Wild-Type FVIIai.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; McMaster University","funders":"","keywords":"Chemistry; Tissue factor; Recombinant DNA; Factor VII; Recombinant factor VIIa; Affinity chromatography; Factor X; Molecular biology; Monoclonal antibody; Mutant; Antibody; Thrombin; Wild type; Thromboplastin; Biochemistry; Factor IX; Coagulation; Enzyme; Platelet; Biology; Immunology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135804,0.0003290378,0.000220244,0.0001383527,0.00007550179,0.0002404653,0.0001689249,0.0002713791,0.003143847],"category_scores_gemma":[0.0002584592,0.0001072473,0.0002077107,0.0001122757,0.0001686261,0.0001469901,0.0001502068,0.0003787704,0.001000792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001661183,"about_ca_system_score_gemma":0.00007832652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002590708,"about_ca_topic_score_gemma":0.0002044515,"domain_scores_codex":[0.9997029,0.0000427768,0.0000337387,0.00006833438,0.000116775,0.00003552973],"domain_scores_gemma":[0.9998394,0.00002816381,0.00004747495,0.00002221328,0.00002074794,0.00004195691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001244026,0.00002436636,0.0002427971,0.00002080582,0.00001200227,0.0000261288,0.000003262951,0.00002850208,0.9982408,0.00003736725,0.00004116812,0.00119833],"study_design_scores_gemma":[0.00005622672,0.0007760618,0.007493568,0.000005889736,0.00002210538,0.001859676,0.000007642629,0.0004865687,0.9836227,0.00005364715,0.005609681,0.000006117014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912115,0.003600717,0.003068036,0.0001301039,0.0000524336,0.00002496661,0.0003567386,0.00009528096,0.00146016],"genre_scores_gemma":[0.9944304,0.0004408679,0.001689079,0.00007323439,0.00001360961,0.00001261552,0.0009756064,0.00001933934,0.002345297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003143847,"threshold_uncertainty_score":0.01051724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02451825332005306,"score_gpt":0.3297990305681437,"score_spread":0.3052807772480906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}