{"id":"W2570028840","doi":"10.1371/journal.pone.0169804","title":"Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Leukotriene B4; Biosynthesis; Leukotriene; Biochemistry; In vitro; Enzyme; Lipid signaling; Lipoxygenase; Arachidonate 5-lipoxygenase; Metabolism; Kinase; In vivo; Biology; Chemistry; Inflammation; Arachidonic acid; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000224509,0.0006387715,0.0006253449,0.0002850575,0.0001850279,0.0003738381,0.0002867078,0.0003473746,0.002322572],"category_scores_gemma":[0.0001326341,0.0001783524,0.000505499,0.0003284054,0.0002205479,0.0001853888,0.0001752598,0.000908885,0.0007487558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003732001,"about_ca_system_score_gemma":0.0005947676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001448615,"about_ca_topic_score_gemma":0.001870478,"domain_scores_codex":[0.9997453,0.00004577267,0.00002938788,0.00003904573,0.00004600097,0.00009445089],"domain_scores_gemma":[0.9999322,0.0000118981,0.00001650089,0.000006873071,0.000008173603,0.0000244334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004316179,0.001040221,0.0003444914,0.0003031967,0.00006130991,0.0001463212,0.00003223741,0.0004885499,0.9806309,0.0002240062,0.0009450855,0.01146756],"study_design_scores_gemma":[0.0005420557,0.004221576,0.003639353,0.00001444903,0.00007563864,0.0003067508,0.00003086654,0.001401072,0.9850344,0.00004638838,0.004676521,0.00001100823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814527,0.01109891,0.001964949,0.00043711,0.0002293196,0.0001053879,0.001121523,0.0002374027,0.003352693],"genre_scores_gemma":[0.9846146,0.006582027,0.00204705,0.0001532069,0.00007110996,0.0001626147,0.002481064,0.00002825625,0.003860165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002322572,"threshold_uncertainty_score":0.007769823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04094079102867832,"score_gpt":0.2502887391422421,"score_spread":0.2093479481135638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}