{"id":"W2570028840","doi":"10.1371/journal.pone.0169804","title":"Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Leukotriene B4; Biosynthesis; Leukotriene; Biochemistry; In vitro; Enzyme; Lipid signaling; Lipoxygenase; Arachidonate 5-lipoxygenase; Metabolism; Kinase; In vivo; Biology; Chemistry; Inflammation; Arachidonic acid; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005930156,0.0002199133,0.0006676354,0.0002950861,0.0001784726,0.00008819524,0.00009805569,0.000128055,0.00002651259],"category_scores_gemma":[0.0008798306,0.0001699717,0.00005163388,0.0001514769,0.000377861,0.0003484639,0.0001687311,0.0003755999,0.000003840876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004534613,"about_ca_system_score_gemma":0.00007262237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00114806,"about_ca_topic_score_gemma":0.0002133184,"domain_scores_codex":[0.9984071,0.00008731124,0.0005442204,0.000379054,0.0003259173,0.0002563593],"domain_scores_gemma":[0.9987535,0.0002219345,0.0003046473,0.0004500894,0.0001415338,0.0001283299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001422085,0.0005395231,0.003413826,0.0001741388,0.00006845525,0.00001895211,0.0009969344,0.000001428925,0.9908393,0.0001908765,0.00002960776,0.002304871],"study_design_scores_gemma":[0.00738641,0.0001288189,0.03014435,0.0006633994,0.0002159625,0.00001986338,0.0002472157,0.0008849864,0.959773,0.0001719013,0.0002012554,0.0001628524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994911,0.001654932,0.00001511623,0.002171802,0.00007555776,0.0006434714,0.00004134671,0.00001964145,0.0004671794],"genre_scores_gemma":[0.9979645,0.0009014299,0.0004134046,0.0001699883,0.0002290517,0.00004843285,0.00002580345,0.00002661012,0.0002207526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03106631,"threshold_uncertainty_score":0.6931243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04094079102867832,"score_gpt":0.2502887391422421,"score_spread":0.2093479481135638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}