{"id":"W2570093446","doi":"10.1093/hmg/ddx001","title":"Cyclodextrin has conflicting actions on autophagy flux <i>in vivo</i> in brains of normal and Alzheimer model mice","year":2017,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; Alzheimer's Association; National Institute of Neurological Disorders and Stroke; National Institute on Aging; University of Alberta","keywords":"Autophagy; Lysosome; Biology; Autophagosome; Cathepsin B; Cell biology; Cathepsin D; Sequestosome 1; Neurodegeneration; Proteostasis; Cathepsin; Tauopathy; Amyloid precursor protein; Population; Biochemistry; Alzheimer's disease; Internal medicine; Medicine; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":{"n_in":0,"stratum":"fund_new","weight":1678.9,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Cyclodextrin effects on autophagy in mouse brains; preclinical neuroscience."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"The work studies autophagy and cyclodextrin effects in disease models, not research itself."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Biomedical study of cyclodextrin effects on autophagy in AD mice; domain neuroscience."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501354,0.0004640601,0.0003471971,0.0004660529,0.0001701326,0.0003402572,0.0001796897,0.0003306851,0.001022963],"category_scores_gemma":[0.0001087999,0.0002116183,0.0002941282,0.000168483,0.0003787262,0.0002994201,0.0001266513,0.0008399008,0.0002330692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003343828,"about_ca_system_score_gemma":0.0002194232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006733384,"about_ca_topic_score_gemma":0.0009005595,"domain_scores_codex":[0.9998564,0.00001539245,0.00001972924,0.00004145646,0.00002067263,0.00004634251],"domain_scores_gemma":[0.9998183,0.00002741767,0.00004333866,0.00002142912,0.00001872548,0.0000707716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009200651,0.00007466321,0.000280993,0.00003635409,0.00001102686,0.00005194488,0.00002185177,0.00002090148,0.9977894,0.0000534397,0.00005015056,0.000689162],"study_design_scores_gemma":[0.00003518532,0.0006189403,0.005207255,0.000007528387,0.00003741474,0.0002827276,0.00003695537,0.0002813306,0.9924844,0.00004678355,0.000954537,0.000006943006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961791,0.001108535,0.0006036757,0.0001246042,0.00003483623,0.00002492151,0.0007625428,0.00008626597,0.00107561],"genre_scores_gemma":[0.9922064,0.001504008,0.00144125,0.0001526764,0.00002187146,0.0001256956,0.00133675,0.00005175492,0.003159508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022963,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06878221894323253,"score_gpt":0.3524858676582051,"score_spread":0.2837036487149726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}