{"id":"W2570216110","doi":"","title":"Cell death ELISAs in the phase I clinical evaluation of AEG35156 (XIAP antisense) administered as an intravenous infusion over 7-days, 3-days, and 2-hours.","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"XIAP; Apoptosis; Programmed cell death; Inhibitor of apoptosis; Pharmacology; Medicine; Cancer; Biology; Caspase; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002067693,0.0002175592,0.0002242692,0.00006684988,0.00007558963,0.00002237504,0.0003003727,0.0003463015,0.00001802915],"category_scores_gemma":[0.00004177072,0.0001814913,0.0001062856,0.000155568,0.0001835004,0.000005452949,0.0000799164,0.0002127803,9.412321e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002605569,"about_ca_system_score_gemma":0.0001900027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001173507,"about_ca_topic_score_gemma":0.0001105202,"domain_scores_codex":[0.997978,0.0004516849,0.0005001306,0.0004666814,0.0003131016,0.000290357],"domain_scores_gemma":[0.9987476,0.00003060661,0.0002212062,0.0006596139,0.0002578825,0.00008303391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002450709,0.0006769787,0.003144702,0.00001247817,0.00006152248,0.00001046693,0.0002231554,0.00001434967,0.9138162,0.0003588555,0.00007719506,0.08135901],"study_design_scores_gemma":[0.003599511,0.002134871,0.01239749,0.00003523305,0.0003296894,0.00003160337,0.0002397048,0.0008232239,0.9555552,0.001210621,0.02322121,0.0004216251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864523,0.003739709,0.008228633,0.0001274501,0.00008095409,0.0007387002,0.0000312356,0.00001280464,0.0005882432],"genre_scores_gemma":[0.9942352,0.001927583,0.001102591,0.002349864,0.0001131822,0.00006315224,0.0001605099,0.0000341457,0.0000137662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08093739,"threshold_uncertainty_score":0.7401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05674874129001793,"score_gpt":0.4219723944185894,"score_spread":0.3652236531285714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}