{"id":"W2570401594","doi":"10.1038/nature20805","title":"Integrated genomic characterization of oesophageal carcinoma","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":1856,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Canada's Michael Smith Genome Sciences Centre; London Health Sciences Centre; Ontario Institute for Cancer Research; BC Cancer Agency","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Human Genome Research Institute; Yonsei University College of Medicine; National Institute of Environmental Health Sciences; Research Institute, Nationwide Children's Hospital; School of Medicine, Indiana University; University of Texas MD Anderson Cancer Center; National Institutes of Health; Peter MacCallum Cancer Centre; Keimyung University; University of Dundee; Chonnam National University; Hospital de Câncer de Barretos; Broad Institute; University of Washington; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Pusan National University; Leidos; University of Pittsburgh; Nationwide Children's Hospital; Van Andel Research Institute; Washington University in St. Louis; Sidney Kimmel Comprehensive Cancer Center; University of Rochester; Yonsei University; University of Southern California; BC Cancer Agency; Vanderbilt University; Case Western Reserve University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Emory University; KU Leuven; Brown University","keywords":"Adenocarcinoma; Cancer research; Esophagus; Pathology; Cancer; Cell of origin; Biology; Carcinoma; Cell; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758888,0.0001392921,0.0002189643,0.001209194,0.0001711823,0.0003172564,0.0001509505,0.0001577763,0.001176558],"category_scores_gemma":[0.000365907,0.00008102688,0.0002270685,0.0007880466,0.0001150099,0.0001165941,0.0002458062,0.0001724591,0.0002931427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002385024,"about_ca_system_score_gemma":0.0002530984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002499682,"about_ca_topic_score_gemma":0.003836368,"domain_scores_codex":[0.9998653,0.00001826197,0.00001181825,0.00004212993,0.00003715167,0.00002533307],"domain_scores_gemma":[0.9998749,0.00002324476,0.00003322144,0.00001663514,0.00003493054,0.00001694018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003725613,0.00003736589,0.2475344,0.0002694375,0.0002157069,0.0009803401,0.0002483232,0.001162266,0.6858929,0.0007202133,0.0006552794,0.06191126],"study_design_scores_gemma":[0.00001185738,0.0001651134,0.9216347,0.00002749246,0.0002231948,0.003184643,0.0003044425,0.001947633,0.05869393,0.0005419976,0.01325351,0.000011442],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761341,0.006197889,0.007548526,0.0001910437,0.00002503808,0.00005764481,0.004864336,0.00009713903,0.004884336],"genre_scores_gemma":[0.9895343,0.001469501,0.00417458,0.0000799662,0.00001380262,0.00002453659,0.003695863,0.00001446501,0.0009929907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002499682,"threshold_uncertainty_score":0.004970312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01637815048767116,"score_gpt":0.3123538912055311,"score_spread":0.29597574071786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}