{"id":"W2570434836","doi":"10.1007/s00439-016-1754-7","title":"Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate","year":2017,"lang":"en","type":"review","venue":"Human Genetics","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; National Institute on Minority Health and Health Disparities; National Institute of Dental and Craniofacial Research; Centers for Disease Control and Prevention; National Institutes of Health","keywords":"Genome-wide association study; Craniofacial; Biology; Genetics; Single-nucleotide polymorphism; Candidate gene; Genetic association; Population; Meta-analysis; Heritability; Bioinformatics; Gene; Medicine; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002048945,0.001173327,0.003077648,0.001325695,0.0001397376,0.0009070215,0.001115375,0.0009303489,0.001845164],"category_scores_gemma":[0.002826516,0.0004065764,0.002778735,0.002059086,0.000273362,0.000527836,0.0006919773,0.001105525,0.0002831392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000469475,"about_ca_system_score_gemma":0.001481511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00272089,"about_ca_topic_score_gemma":0.009453541,"domain_scores_codex":[0.9995481,0.0001083816,0.00009405819,0.0001286906,0.00008892783,0.00003188252],"domain_scores_gemma":[0.9986028,0.0009788709,0.0001831764,0.00004333488,0.0001403872,0.00005145614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001284517,0.000057983,0.01963296,0.0746047,0.04379898,0.0007758935,0.000151382,0.0008515382,0.001753421,0.001662541,0.02145418,0.8339718],"study_design_scores_gemma":[0.0009846012,0.0006918301,0.1118868,0.038877,0.2304051,0.005977903,0.0005210214,0.0007534584,0.00221778,0.01026125,0.5971522,0.0002710258],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006262379,0.9985915,0.0001508865,0.0002722375,0.0000887252,0.000003268689,0.0001258591,0.000005314913,0.0001359866],"genre_scores_gemma":[0.006573892,0.9916981,0.0005290683,0.0005162589,0.0002082002,0.000009623014,0.0002732273,0.000004092535,0.0001875376],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003077648,"threshold_uncertainty_score":0.01083595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3369911380236479,"score_gpt":0.4655392916684474,"score_spread":0.1285481536447994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}