{"id":"W2570434836","doi":"10.1007/s00439-016-1754-7","title":"Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate","year":2017,"lang":"en","type":"review","venue":"Human Genetics","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; National Institute on Minority Health and Health Disparities; National Institute of Dental and Craniofacial Research; Centers for Disease Control and Prevention; National Institutes of Health","keywords":"Genome-wide association study; Craniofacial; Biology; Genetics; Single-nucleotide polymorphism; Candidate gene; Genetic association; Population; Meta-analysis; Heritability; Bioinformatics; Gene; Medicine; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008506121,0.0008570519,0.003005764,0.0002741839,0.0005424173,0.0003423617,0.0006153762,0.0009081364,0.000050954],"category_scores_gemma":[0.0001555829,0.0006462428,0.0005019474,0.0001218689,0.0006883119,0.00001818934,0.0007772704,0.0005290117,0.000005919778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000393066,"about_ca_system_score_gemma":0.0004113706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001203044,"about_ca_topic_score_gemma":0.0007439777,"domain_scores_codex":[0.9960988,0.0003202297,0.001173853,0.001190778,0.0005287473,0.0006876364],"domain_scores_gemma":[0.9969536,0.0001677639,0.001152198,0.001047768,0.0002692159,0.0004094261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002648223,0.0004504309,0.7678569,0.01750148,0.08130873,0.0001101856,0.001134875,0.00001217825,0.01755978,0.0000399159,0.0007708372,0.1129899],"study_design_scores_gemma":[0.002219468,0.00110397,0.4766057,0.000757728,0.03787006,0.0001542288,0.00003859362,0.000008238118,0.0002065716,0.00006464465,0.4790757,0.001895138],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4711301,0.5244914,0.0001159207,0.00003935947,0.00009794515,0.001706615,0.002166779,0.00002467786,0.0002271539],"genre_scores_gemma":[0.09872074,0.8977688,0.0005946483,0.00003149098,0.0004191938,0.00004660895,0.001314964,0.000152534,0.0009510495],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4783048,"threshold_uncertainty_score":0.9995989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3369911380236479,"score_gpt":0.4655392916684474,"score_spread":0.1285481536447994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}